Žurnal obŝej himii

New 1-(2-hydroxyethyl)- and 1-(4-hydroxyphenyl)-5-aryl-4-aroyl-3-hydroxy-3-pyrroline-2-ones were synthesized by the reaction of methyl esters of aroylpyruvic acids, aromatic aldehydes and ethanolamine (p-aminophenol). The antimicrobial and antinociceptive activity of the obtained compounds was studied.

The synthesis of new original molecules of isobornyl phenols containing a thiocyanate group was reported. It was found that the selectivity of the nucleophilic substitution reaction is significantly influenced by such structural factors as the nature of the halide and the length of the aliphatic linker. In the case of 2,6-diisobornyl-4-bromomethylphenol, the thiocyanate was obtained at 0°C. For isobornylphenols with a propyl linker, thiocyanates were synthesized by boiling in the appropriate solvent. The obtained thiocyanate derivatives of isobornyl phenols can be considered as promising inhibitors of oxidative processes due to several reaction centers in their structure.

Phosphonyl-substituted cyclopropanes were obtained by the reaction of O,O-diethyl (1,2-dibromoethyl)phosphonate with CH-acids, in particular, acetylacetone, acetoacetic and malonic esters, ethyl ester and amide of cyanoacetic acid, and benzyl cyanide, in the presence of a base in acetonitrile at room temperature. Antibacterial activity of the starting phosphonate and its derivatives was studied.

A new approach to the synthesis of highly dispersed barium carbonate with specified characteristics (bulk density from 0.015 g/cm³, particle size in the range of 13–142 nm, isometric habit) was developed. It consists in sequential heat treatment up to 1100℃ of a concentrated aqueous-carbohydrate solution of Ba(NO₃)₂ and D-glucose. The processes of barium carbonate phase formation in the temperature range used (350–1100°C) were studied. The main stages of BaCO₃ synthesis were characterized using physicochemical methods (IR spectroscopy, X-ray phase analysis, transmission electron microscopy, scanning electron microscopy), as well as chemical analysis.

The effect of the chelate complex compound Na₄[NiN(CH₂PO₃)₃]‧11H₂O on the composition, surface concentration profile and corrosion-electrochemical behavior of the 20 steel in a borate buffer solution at pH = 7.4 and natural aeration was studied using the potentiodynamic method, X-ray photoelectron spectroscopy and scanning electron microscopy of the surface with microanalysis. The studied compound is a corrosion inhibitor; the best protective effect achieved at a concentration of 0.5 mmol/dm³. The mechanism of the inhibitory action of this inhibitor is discussed. Slowing down the anodic dissolution of iron is due to the formation of a nickel-doped layer of Fe_n–xNi_xO_m oxides with a thickness of 10–20 nm on the steel surface. The mechanism of action of the studied corrosion inhibitor differs sharply from the mechanism of action of the previously studied inhibitors Na₄[CuN(CH₂PO₃)₃]‧13H₂O and Na₄[ZnN(CH₂PO₃)₃]‧13H₂O.