Synthesis and Structure of Diethyl 2-[(Aryl)-(Morpholino/Piperidin-1-Yl)Methyl]Malonates

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Abstract

A three-component reaction of diethyl malonate with aromatic aldehyde, morpholine or piperidine during boiling in ethanol for 4 h produced diethyl 2-[(aryl)(morpholino/piperidin-1-yl)methyl]malonates. Structure of the compounds was determined by 1H, 13C NMR spectroscopy and single crystal X-ray diffraction analysis.

About the authors

K. V. Podchezertseva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
Perm, 614990 Russia

A. S. Homan

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
Perm, 614990 Russia

T. M. Zamaraeva

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: tanyapgfa@yandex.ru
Perm, 614990 Russia

M. V. Dmitriev

Perm State National Research University

Author for correspondence.
Email: tanyapgfa@yandex.ru
Perm, 614068 Russia

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