Synthesis and Biological Activity of 1-Hydroxyethyl- and 1-(4-Hydroxyphenyl)-5-Aryl-4-Aroyl-3-Pyrrolin-2-Ones

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Abstract

New 1-(2-hydroxyethyl)- and 1-(4-hydroxyphenyl)-5-aryl-4-aroyl-3-hydroxy-3-pyrroline-2-ones were synthesized by the reaction of methyl esters of aroylpyruvic acids, aromatic aldehydes and ethanolamine (p-aminophenol). The antimicrobial and antinociceptive activity of the obtained compounds was studied.

About the authors

V. L. Gein

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

V. A. Batov

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

D. F. Rubtsov

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

N. V. Nosova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation; Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia; Perm, 614990 Russia

I. G. Mokrushin

Perm State National Research University

Email: geinvl48@mail.ru
Perm, 614068 Russia

L. F. Gein

Perm State Medical University named after Academician E. A. Wagner of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

A. A. Gagarina

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

V. V. Novikova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: geinvl48@mail.ru
Perm, 614990 Russia

R. R. Makhmudov

Perm State National Research University; Federal Scientific Center for Medical and Preventive Technologies for Health Risk Management

Author for correspondence.
Email: geinvl48@mail.ru
Perm, 614068 Russia; Perm, 614045 Russia

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