The Role of TNF-α, TNFRSF1A, and CD40 Genes Polymorfisms in Multiple Sclerosis in Tomsk Region

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Abstract

We studied the role of polymorphisms rs1800629 of the TNF-α gene; rs4149584 of the TNFRSF1A gene; rs6074022, rs1883832, rs1535045, rs11086996 of the CD40 gene in the onset, clinical course and response to treatment in multiple sclerosis (MS) in a group of 152 patients, living in Tomsk region. 707 volunteers without autoimmune diseases and pathology of the nervous system were included in control group. The allele C of the rs6074022 polymorphism of CD40 gene was associated with the risk of MS and contributed to the high rate of disease progression. The T allele of the rs6074022 polymorphism of CD40 gene showed a significant association with the average rate of disease progression, and the GA genotype of rs1800629 polymorphism of TNF-α gene was associated with a higher frequency of MS exacerbations. Other polymorphisms did not demonstrate an association with both the risk of disease, the clinical features and response to treatment.

About the authors

M. A. Titova

Siberian State Medical University, Neurology and Neurosurgery Department

Email: nchjournal@gmail.com
Russia, Tomsk

V. M. Alifirova

Siberian State Medical University, Neurology and Neurosurgery Department

Email: nchjournal@gmail.com
Russia, Tomsk

N. F. Musina

Siberian State Medical University, Neurology and Neurosurgery Department

Email: nchjournal@gmail.com
Russia, Tomsk

T. N. Nikolaeva

Siberian State Medical University, Neurology Clinic

Email: nchjournal@gmail.com
Russia, Tomsk

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