The role of the serotoninergic system in functional recovery after spinal cord injury

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The serotoninergic system plays an essential role in the modulation of the spinal networks activity involved in the control of motor, sensory, and visceral functions. Spinal cord injury (SCI) can induce a state of overexcitation that contributes to pain, spasticity, and dysregulation of autonomic functions. At the same time, 5-NT axons are known to adapt faster than others to pathophysiologic changes and leave the ability to sprout and regenerate after injury. A number of experimental animal studies as well as some clinical observations suggest that the serotoninergic system is a key endogenous resource for posttraumatic recovery after SCI. Specific therapy may include administration of serotoninergic drugs and intraspinal transplantation of 5-NT neurons. This review discusses the role of the serotoninergic system in functional recovery after SCI and the prospects for the use of serotoninergic drugs in neurorehabilitation.

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S. Konovalova

Sirius University of Science and Technology

Email: musienko.pe@talantiuspeh.ru

Scientific Center of Genetics and Life Sciences, Department of Neurobiology

Rússia, Federal Territory of Sirius

Y. Sysoev

Sirius University of Science and Technology; Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg State University

Email: musienko.pe@talantiuspeh.ru

Scientific Center of Genetics and Life Sciences, Department of Neurobiology; Institute of Translational Biomedicine

Rússia, Federal Territory of Sirius; St. Petersburg; St. Petersburg

A. Vetlugina

Sirius University of Science and Technology

Email: musienko.pe@talantiuspeh.ru

Scientific Center of Genetics and Life Sciences, Department of Neurobiology

Rússia, Federal Territory of Sirius

K. Arsentiev

Sirius University of Science and Technology

Email: musienko.pe@talantiuspeh.ru

Scientific Center of Genetics and Life Sciences, Department of Neurobiology

Rússia, Federal Territory of Sirius

P. Musienko

Sirius University of Science and Technology; Life Improvement by Future Technologies Center “LIFT”; Federal Center of Brain Research and Neurotechnologies

Autor responsável pela correspondência
Email: musienko.pe@talantiuspeh.ru

Scientific Center of Genetics and Life Sciences, Department of Neurobiology

Rússia, Federal Territory of Sirius; Moscow; Moscow

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2. Fig. 1. Pathogenetic picture of the spinal cord injury area.

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3. Fig. 2. Descending serotonergic projections innervating spinal neural networks.

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4. Fig. 3. The relationship between the severity of psychoemotional disorders and the effectiveness of neurorehabilitation procedures.

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