Enviar artigo por via de e-mail Efficacy of poloxamer 188 in aplastic anemia model induced by carboplatin in CBA mice
- Autores: Kholina A.V.1,2, Palikov V.A.1, Borozdina N.A.1, Kravchenko I.N.1, Pakhomova I.A.1, Dalevich R.A.1,2, Hajiguliyeva S.Z.1, Arshintseva E.V.3, Pushkin S.Y.3, Dyachenko I.A.1, Murashev A.N.1
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Afiliações:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
- Medical emulsions LLC
- Edição: Volume 520, Nº 1 (2025)
- Páginas: 26-30
- Seção: Articles
- URL: https://vietnamjournal.ru/2686-7389/article/view/682023
- DOI: https://doi.org/10.31857/S2686738925010056
- EDN: https://elibrary.ru/tcybfa
- ID: 682023
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Resumo
The efficacy of poloxamer 188 on medullary hematopoiesis in aplastic anemia was investigated. The present study demonstrated that poloxamer 188 at doses of 10 mg/kg, 100 mg/kg and 500 mg/kg administered via oral gavage in CBA mice, in the context of the development of anemia, a dose-dependent effect was observed, characterized by an increase in erythrocyte, hemoglobin and reticulocyte numbers. In the group with carboplatin, these parameters were decreased on day 21, indicating mild anemia. It has been established that P188 has the capacity to exert a beneficial influence on the blood cell composition, which is disrupted by cytostatic drugs.
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Sobre autores
A. Kholina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Email: borozdina@bibch.ru
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Rússia, Pushchino; PushchinoV. Palikov
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Rússia, PushchinoN. Borozdina
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Autor responsável pela correspondência
Email: borozdina@bibch.ru
Branch
Rússia, PushchinoI. Kravchenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Rússia, PushchinoI. Pakhomova
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Rússia, PushchinoR. Dalevich
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Email: borozdina@bibch.ru
Branch of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Pushchino Branch of the Federal State Budgetary Educational Institution of Higher Education “Russian Biotechnological University (BIOTECH University)”
Rússia, Pushchino; PushchinoS. Hajiguliyeva
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Rússia, PushchinoE. Arshintseva
Medical emulsions LLC
Email: borozdina@bibch.ru
Rússia, Serpukhov
S. Pushkin
Medical emulsions LLC
Email: borozdina@bibch.ru
Rússia, Serpukhov
I. Dyachenko
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Rússia, PushchinoA. Murashev
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: borozdina@bibch.ru
Branch
Rússia, PushchinoBibliografia
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