Stratified Mucin-Producing Intraepithelial Lesion of the Cervix in an HPV-16 Positive Woman: A Rare Encounter
- Authors: Kumar N.1, Mangla M.1, Palo S.1, Gabbeta S.1, Aparna J.1
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Affiliations:
- Department of Obstetrics and Gynecology, All India Institute of Medical Sciences
- Issue: Vol 24, No 6 (2024)
- Section: Medicine
- URL: https://vietnamjournal.ru/1871-5265/article/view/645729
- DOI: https://doi.org/10.2174/0118715265284722240110114107
- ID: 645729
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Abstract
Background:Cervical cancer is the fourth most common cancer among women globally and has a strong association with Human Papillomavirus (HPV) infection. Stratified mucinproducing intraepithelial lesion (SMILE), a variant of Adenocarcinoma in situ (AIS), is a rare cervical precancer lesion that is often missed or detected incidentally.
Case Presentation:The present case report briefs the finding of a 39-year-old woman who presented to the gynecological outpatient department with complaints of vaginal discharge for 6-8 months. She had no history of irregular menstrual cycles or postcoital bleeding. Her routine Pap smear revealed atypical squamous cells of undetermined significance (ASCUS) and was positive for HPV-16 type. Her cervical biopsy report revealed AIS and her histopathological report of hysterectomy revealed SMILE, a variant of AIS.
Discussion:The SMILE variant of AIS is a rare cervical precancerous lesion characterized by the morphological overlap of both squamous intraepithelial lesions and AIS. It is often difficult to diagnose on Pap smear and is commonly associated with high-risk HPV infections. The management of SMILE is the same as that for AIS, which is the excisional procedure followed by a hysterectomy if the margins are negative and depending on the fertility desires of the patient, followed by regular follow-up with HPV testing.
Conclusion:SMILE is a rare variant of AIS, which is often missed on cytological screening of the cervix. It is commonly associated with high-risk types of HPV. Hence, incorporating HPV testing in the screening of cervical cancer is important and recommended to increase the overall sensitivity of screening for adenocarcinoma lesions.
About the authors
Naina Kumar
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences
Author for correspondence.
Email: info@benthamscience.net
Mishu Mangla
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences
Email: info@benthamscience.net
Seetu Palo
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences
Email: info@benthamscience.net
Spandana Gabbeta
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences
Email: info@benthamscience.net
J. Aparna
Department of Obstetrics and Gynecology, All India Institute of Medical Sciences
Email: info@benthamscience.net
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