A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing Ulcers - Case Series


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Abstract

Introduction::Appropriate care and treatment of a wound is the need of the hour whether it is an infected or a non-infected wound. If wound healing is delayed for some reason, it leads to serious complications and further increases the hospital stay and cost of treatment. Herein, we describe a novel antimicrobial wound dressing formulation (VG111), with an objective to generate the preliminary data showing the distinct advantages in various types of wounds.

Method::This case series involved the treatment of acute cases of wounds or chronic wounds that did not respond well to conventional wound healing treatments with VG111 in patients with different etiologies. Thirteen cases of patients that included patients with diabetes, pressure ulcers, burns, trauma, and others treated with VG111 showed rapid wound healing in all the cases even obviating the need for a graft when complete skin regeneration occurred.

Result::This was illustrated by clearing of the wound infections, reduction/disappearance of the exudate, appearance of intense granulation, epithelialization, and anti-biofilm activity followed by complete wound closure. This VG111 precludes the need for systemic antimicrobial agents in localized infections and therefore, this single agent is an attempt to address the limitations and the drawbacks of the available products.

Conclusion::Despite patients belonging to the old age group and having comorbidities like diabetes, still VG111 showed effective rapid wound healing, and that too without any scar formation in hardto- heal, infected, and non-infected wounds.

About the authors

Sarabpreet Singh

Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research

Email: info@benthamscience.net

Arun Kumar Aggarwal

Radiation oncology, Aadhar Hospital

Email: info@benthamscience.net

Rajendra Gudisa

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research

Email: info@benthamscience.net

Priyam Batra

Department of Medical Microbiology, All India Institute of Medical Sciences

Email: info@benthamscience.net

Nitesh Kumar Rathi

Department of Orthopaedics, Saveetha Institute of Medical and Technical Sciences

Email: info@benthamscience.net

Vibha Madan

, Miri Piri Hospital

Email: info@benthamscience.net

Vipul Thakur

Department of General Surgery, Post Graduate Institute of Medical Education and Research

Email: info@benthamscience.net

Harish Sharma

General Surgery, Aadhar Hospital

Email: info@benthamscience.net

Rajesh Kumar

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research

Email: info@benthamscience.net

Siddhant Khare

Department of General Surgery, Post Graduate Institute of Medical Education and Research

Email: info@benthamscience.net

Lipika Singhal

Department of Microbiology, Government Medical College and Hospital

Email: info@benthamscience.net

Rama Chaudhry

Department of Medical Microbiology, All India Institute of Medical Sciences

Email: info@benthamscience.net

Neeraj Arora

Department of Microbiology, Civil Hospital

Email: info@benthamscience.net

Hardeep Singh

Department of General Surgery, Civil Hospital

Email: info@benthamscience.net

Jasjeet Kaur

, CMO, MT SAKET Hospital and Physiotherapy College

Email: info@benthamscience.net

Ashish Sharma

Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research

Email: info@benthamscience.net

Ganesh Dakhale

Department of Pharmacology, All India Institute of Medical Sciences (AIIMS)

Email: info@benthamscience.net

Vijay Sharma

Department of Orthopedics, Jai Prakash Narayan Apex Trauma Center (JPNATC), All India Institute of Medical Sciences (AIIMS)

Email: info@benthamscience.net

Vikas Gautam

Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research

Author for correspondence.
Email: info@benthamscience.net

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