Spontaneous Intracranial Hemorrhage and Acute Respiratory Distress Syndrome Associated with Dengue: A Case Report


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Abstract

Background::Dengue is a major health burden worldwide, notably in tropical and subtropical countries, with symptoms ranging from asymptomatic infection to severe hemorrhagic or shock syndrome. The clinical and biochemical profile of dengue has been shown in the literature to be expanding as more atypical signs have been added over the past few decades. Most dengue-related symptoms are typically mild to moderate and self-limited. However, intracranial hemorrhage and acute respiratory distress syndrome in severe dengue is an event that has been encountered uncommonly.

Case presentation::A 30-year-old female presented with complaints of fever, headache, cough, and altered sensorium. Later, she was diagnosed with severe dengue fever complicated by dengue hemorrhagic fever, which manifested as subarachnoid and subdural bleeding and acute respiratory distress syndrome. She was managed conservatively with a positive outcome.

Conclusion::Atypical manifestation, though rare, should be kept in mind while dealing with severe dengue patients, as early detection based on anticipated risk factors and timely treatment have the potential to save lives.

About the authors

Kailash Kumar

Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University

Email: info@benthamscience.net

Santosh Singh

Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University

Email: info@benthamscience.net

Jitendra Singh

Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University

Email: info@benthamscience.net

Bhavya J.

Department of General Medicine, Institute of Medical Science, Banaras Hindu University

Email: info@benthamscience.net

Anju Dinkar

Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Nilesh Kumar

Department of General Medicine, Institute of Medical Sciences, Banaras Hindu University

Email: info@benthamscience.net

References

  1. Zeng Z, Zhan J, Chen L, Chen H, Cheng S. Global, regional, and national dengue burden from 1990 to 2017: A systematic analysis based on the global burden of disease study 2017. EClinicalMedicine 2021; 32: 100712. doi: 10.1016/j.eclinm.2020.100712 PMID: 33681736
  2. Mondal N. The resurgence of dengue epidemic and climate change in India. Lancet 2023; 401(10378): 727-8. doi: 10.1016/S0140-6736(23)00226-X PMID: 36870720
  3. Singh J, Dinkar A, Atam V, et al. Intracranial hemorrhage in dengue fever; a case series. J Med Sci Clin Res 2015; 3: 4447-52.
  4. Mustafa MS, Rasotgi V, Jain S, Gupta V. Discovery of fifth serotype of dengue virus (DENV-5): A new public health dilemma in dengue control. Med J Armed Forces India 2015; 71(1): 67-70. doi: 10.1016/j.mjafi.2014.09.011 PMID: 25609867
  5. Gallin J, Fauci A. Emerging Infections Academic Press. 1998. Available from: https://books.google.com/
  6. Singh J, Singh A, Dinkar A, Atam V. A rare presentation of dengue fever: acute motor quadriparesis due to hypokalemia. International Journal of Research in Medical Sciences 2014; 2(4): 1732. doi: 10.5455/2320-6012.ijrms20141196
  7. Singh J, Dinkar A, Atam V, et al. Awareness and outcome of changing trends in clinical profile of dengue fever: A retrospective analysis of dengue epidemic from January to December 2014 at a Tertiary Care Hospital. J Assoc Physicians India 2017; 65(5): 42-6. PMID: 28598047
  8. WHO 2009- World Health Organization (2009) Dengue guidelines for diagnosis, treatment, prevention and control: new edition World Health Organization 2009. Available from: https://apps.who.int/iris/handle/10665/44188(Accessed on 2023 August 16).
  9. Country Office for India, World Health Organization. (2015) National guidelines for clinical management of dengue fever WHO Country Office for India. Available from: https://apps.who.int/iris/handle/10665/208893(Accessed on 2023 August 16).
  10. Singh J, Dinkar A, Atam V, Misra R, Kumar S. A deadly combination of acute encephalitis and gastric hemorrhage in dengue fever: A rare case. J Med Sci Clin Res 2014; 12(2): 3187-91.
  11. Murthy JMK. Neurological complication of dengue infection. Neurol India 2010; 58(4): 581-4. doi: 10.4103/0028-3886.68654 PMID: 20739796
  12. Bharti P, Bala K. Subdural effusion in dengue patient as a late neurological complication: a rare case report. J Clin Diagn Res 2015; 9(7): 01-2.
  13. Lum LCS, Choy YS, Harun F, George R, Lam SK. Dengue encephalitis: a true entity? Am J Trop Med Hyg 1996; 54(3): 256-9. doi: 10.4269/ajtmh.1996.54.256 PMID: 8600761
  14. Kulkarni R, Pujari S, Gupta D. Neurological manifestations of dengue fever. Ann Indian Acad Neurol 2021; 24(5): 693-702. doi: 10.4103/aian.AIAN_157_21 PMID: 35002126
  15. Chang K, Huang CH, Chen TC, Lin CY, Lu PL, Chen YH. Clinical characteristics and risk factors for intracranial hemorrhage or infarction in patients with dengue. J Microbiol Immunol Infect 2021; 54(5): 885-92. doi: 10.1016/j.jmii.2021.03.009 PMID: 33840603
  16. Gautam S, Meena R, Meena S, Gautam B. Retrospective analysis of prognostic factors in dengue infected patients with intracranial bleed. Surg Neurol Int 2016; 7(40) (Suppl. 39): 935. doi: 10.4103/2152-7806.195229 PMID: 28031986
  17. Carod-Artal FJ, Wichmann O, Farrar J, Gascón J. Neurological complications of dengue virus infection. Lancet Neurol 2013; 12(9): 906-19. doi: 10.1016/S1474-4422(13)70150-9 PMID: 23948177
  18. Cam BV, Heegaard ED, Poulsen A, Hue NB, Fonsmark L, Phuong NT. Prospective case-control study of encephalopathy in children with dengue hemorrhagic fever. Am J Trop Med Hyg 2001; 65(6): 848-51. doi: 10.4269/ajtmh.2001.65.848 PMID: 11791985
  19. Shivbalan S, Anandnathan K, Balasubramanian S, Datta M, Amalraj E. Predictors of spontaneous bleeding in Dengue. Indian J Pediatr 2004; 71(1): 33-6. doi: 10.1007/BF02725653 PMID: 14979383
  20. Attavinijtrakarn P. Hepatic dysfunction in dengue haemorrhagic fever in Paholpolpayuhasaena Hospital. Thai J Pediatr 2000; 39: 265-76.
  21. Chamnanchanunt S, Kanagaraj D, Thanachartwet V, Desakorn V, Rojnuckarin P. Early predictors of clinically significant bleeding in adults with dengue infection. Southeast Asian J Trop Med Public Health 2012; 43(4): 890-9. PMID: 23077811
  22. Dinkar A, Singh J, Singh R, Siddiqui M, Sinha N, Singh S. Clinical profile of dengue fever and coinfection with chikungunya. Tzu-Chi Med J 2018; 30(3): 158-64. doi: 10.4103/tcmj.tcmj_138_17 PMID: 30069124
  23. Mehmood A, Afzal MW, Ahmad M, Mufti M, Malik J, Zaidi SMJ. Respiratory sequelae of dengue fever. Trop Doct 2023; 53(2): 237-40. doi: 10.1177/00494755221127355 PMID: 36579820
  24. Marchiori E, Hochhegger B, Zanetti G. Pulmonary manifestations of dengue. J Bras Pneumol 2020; 46(1): e20190246. doi: 10.1590/1806-3713/e20190246 PMID: 32130344
  25. de Almeida RR, Paim B, de Oliveira SA, et al. Dengue hemorrhagic fever: A state-of-the-art review focused in pulmonary involvement. Lung 2017; 195(4): 389-95. doi: 10.1007/s00408-017-0021-6 PMID: 28612239
  26. Marchiori E, von Ranke F, Zanetti G, Hochhegger B. Dengue hemorrhagic fever: Another cause of diffuse alveolar hemorrhage in immunocompetent patients. Respir Med 2012; 106(12): 1807-8. doi: 10.1016/j.rmed.2012.07.014 PMID: 22959008

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