The Unsuspected Role of the Renin-Angiotensin System (RAS): Could its Dysregulation be at the Root of All Non-Genetic Human Diseases?


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About the authors

Ziad Fajloun

Faculty of Sciences 3, Department of Biology, Lebanese University, Campus Michel Slayman Ras Maska

Email: info@benthamscience.net

Jean-Marc Sabatier

, Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol

Author for correspondence.
Email: info@benthamscience.net

References

  1. Magazine R, Chogtu B, Bhat A. Role of angiotensin converting enzyme-2 and its modulation in disease: Exploring new frontiers. Med Pharm Rep 2023; 96(2): 146-53. doi: 10.15386/mpr-2345 PMID: 37197279
  2. Balakumar P, Handa S, Alqahtani A, et al. Unraveling the differentially articulated axes of the century-old renin–angiotensin–aldosterone system: Potential therapeutic implications. Cardiovasc Toxicol 2022; 22(3): 246-53. doi: 10.1007/s12012-022-09724-y PMID: 35143015
  3. Perlot T, Penninger JM. ACE2 – From the renin–angiotensin system to gut microbiota and malnutrition. Microbes Infect 2013; 15(13): 866-73. doi: 10.1016/j.micinf.2013.08.003 PMID: 23962453
  4. Annweiler C, Cao Z, Wu Y, et al. Counter-regulatory ‘renin-angiotensin’ system-based candidate drugs to treat COVID-19 diseases in SARS-CoV-2-infected patients. Infect Disord Drug Targets 2020; 20(4): 407-8. doi: 10.2174/22123989MTA2cNzIlw PMID: 32418532
  5. Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, et al. Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis 2016; 7(10): e2427. doi: 10.1038/cddis.2016.327 PMID: 27763643
  6. Chen F, Chen B, Xiao FQ, et al. Autophagy protects against senescence and apoptosis via the RAS-mitochondria in high-glucose-induced endothelial cells. Cell Physiol Biochem 2014; 33(4): 1058-74. doi: 10.1159/000358676 PMID: 24732710
  7. Coto E, Avanzas P, Gómez J. The renin–angiotensin–aldosterone system and coronavirus disease 2019. Eur Cardiol 2021; 16: e07. doi: 10.15420/ecr.2020.30 PMID: 33737961
  8. El-Arif G, Farhat A, Khazaal S, et al. The renin-angiotensin system: A key role in SARS-CoV-2-induced COVID-19. Molecules 2021; 26(22): 6945. doi: 10.3390/molecules26226945 PMID: 34834033
  9. El-Arif G, Khazaal S, Farhat A, et al. Angiotensin II type i receptor (AT1R): The gate towards COVID-19-associated diseases. Molecules 2022; 27(7): 2048. doi: 10.3390/molecules27072048 PMID: 35408447
  10. Khazaal S, Harb J, Rima M, et al. The pathophysiology of long COVID throughout the renin-angiotensin system. Molecules 2022; 27(9): 2903. doi: 10.3390/molecules27092903 PMID: 35566253
  11. Harb J, Debs N, Rima M, et al. SARS-CoV-2, COVID-19, and reproduction: Effects on fertility, pregnancy, and neonatal life. Biomedicines 2022; 10(8): 1775. doi: 10.3390/biomedicines10081775 PMID: 35892675
  12. Sabatier J-M, Fajloun Z, Legros C. COVID-19 and ehlers-danlos syndrome: The dangers of the spike protein of SARS-CoV-2. Infect Disord Drug Targets 2023; 23(3): e040123212375. doi: 10.2174/1871526523666230104145108 PMID: 36600622
  13. Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. Why do athletes develop very severe or fatal forms of COVID after intense exercise following SARS-CoV-2 infection or anti-COVID vaccination? Infect Disord Drug Targets 2023; 23(4): e110123212563. doi: 10.2174/1871526523666230111104355 PMID: 36631923
  14. Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. SIBO: The trail of a "new" human pathology associated with multiple severe and disabling COVID-19 and long COVID symptoms or induced by the anti-COVID-19 vaccine. Infect Disord Drug Targets 2023; 23(4): e100223213593. doi: 10.2174/1871526523666230210162334 PMID: 36762752
  15. Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. Anti-COVID-19 vaccination, COVID-19, and female contraception: The exacerbated risks (thromboembolism) of the estrogen-progestin pill. Infect Disord Drug Targets 2023; 23(4): e240223214000. doi: 10.2174/1871526523666230224094439 PMID: 36823996
  16. Fajloun Z, Abi Khattar Z, Kovacic H, Legros C, Sabatier JM. Understanding and relieving of neuropathic disorders in the long COVID. Infect Disord Drug Targets 2023; 23(4): e270223214061. doi: 10.2174/1871526523666230227113205 PMID: 36843369
  17. Fajloun Z, Abi Khattar Z, Kovacic H, Sabatier JM. COVID-19 and anti-COVID-19 vaccination: Potential damages to the thyroid gland. Infect Disord Drug Targets 2023; 23(6): e090523216698. Epub ahead of print doi: 10.2174/1871526523666230509112038 PMID: 37165584
  18. Sabatier J-M, Fajloun Z, Wu Y, Cao Z, Kovacic H. Covid-19 and Alzheimer’s Disease: The link finally established. Infect Disord Drug Targets 2023; 23. Epub ahead of print doi: 10.2174/1871526523666230529162633 PMID: 37254552
  19. Sabatier J-M, Fajloun Z, Wu Y, Cao Z, Kovacic H. Covid-19 and Parkinson’s Disease: The link also established! Infect Disord Drug Targets 2023; 23. Epub ahead of print doi: 10.2174/1871526523666230619104142 PMID: 37340743
  20. Yamamoto N, Ariumi Y, Nishida N, et al. SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype. Gene 2020; 758: 144944. doi: 10.1016/j.gene.2020.144944 PMID: 32628976
  21. Hatami N, Ahi S, Sadeghinikoo A, et al. Worldwide ACE (I/D) polymorphism may affect COVID-19 recovery rate: An ecological meta-regression. Endocrine 2020; 68(3): 479-84. doi: 10.1007/s12020-020-02381-7 PMID: 32542429
  22. I’ñiguez M, PeÀrez-Matute P, Villoslada-Blanco P, et al. ACE gene variants rise the risk of severe COVID-19 in patients with hypertension, dyslipidemia or diabetes: A spanish pilot study. Front Endocrinol 2021; 12: 688071.
  23. Verma S, Abbas M, Verma S, et al. Impact of I/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients. Infect Genet Evol 2021; 91: 104801. doi: 10.1016/j.meegid.2021.104801 PMID: 33676010
  24. Nejat R, Sadr AS. Are losartan and imatinib effective against SARS-CoV2 pathogenesis? A pathophysiologic-based in silico study. In Silico Pharmacol 2020; 9(1): 1. doi: 10.1007/s40203-020-00058-7 PMID: 33294307
  25. Costa LB, Perez LG, Palmeira VA, et al. Insights on SARS-CoV-2 molecular interactions with the renin-angiotensin system. Front Cell Dev Biol 2020; 8: 559841. doi: 10.3389/fcell.2020.559841 PMID: 33042994
  26. Dielis AWJH, Smid M, Spronk HMH, et al. The prothrombotic paradox of hypertension: Role of the renin-angiotensin and kallikrein-kinin systems. Hypertension 2005; 46(6): 1236-42. doi: 10.1161/01.HYP.0000193538.20705.23 PMID: 16286563
  27. Lumpuy-Castillo J, Lorenzo-Almorós A, Pello-Lázaro AM, et al. Cardiovascular damage in COVID-19: Therapeutic approaches targeting the renin-angiotensin-aldosterone system. Int J Mol Sci 2020; 21(18): 6471. doi: 10.3390/ijms21186471 PMID: 32899833
  28. Grammatopoulos TN, Jones SM, Ahmadi FA, et al. Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra. Mol Neurodegener 2007; 2(1): 1. doi: 10.1186/1750-1326-2-1 PMID: 17224059
  29. He L, Du J, Chen Y, et al. Renin-angiotensin system promotes colonic inflammation by inducing T H 17 activation via JAK2/STAT pathway. Am J Physiol Gastrointest Liver Physiol 2019; 316(6): G774-84. doi: 10.1152/ajpgi.00053.2019 PMID: 30995068
  30. Pang XC, Zhang HX, Zhang Z, Rinkiko S, Cui YM, Zhu YZ. The two-way switch role of ACE2 in the treatment of novel coronavirus pneumonia and underlying comorbidities. Molecules 2020; 26(1): 142. doi: 10.3390/molecules26010142 PMID: 33396184
  31. Lin J, Hu FB, Qi L, Curhan GC. Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus. BMC Nephrol 2009; 10(1): 9. doi: 10.1186/1471-2369-10-9 PMID: 19327134

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