Recent Approaches to Enhance Osteogenesis of Dental Pulp Stem Cells on Electrospun Scaffolds


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Abstract

Critical-sized bone defects are a challenging issue during bone regeneration. Bone tissue engineering is aimed to repair such defects using biomimicking scaffolds and stem cells. Electrospinning allows the fabrication of biocompatible, biodegradable, and strengthened scaffolds for bone regeneration. Natural and synthetic polymers, alone or in combination, have been employed to fabricate scaffolds with appropriate properties for the osteogenic differentiation of stem cells. Dental pulps are rich in stem cells, and dental pulp stem cells (DPSCs) have a high capacity for proliferation, differentiation, immunomodulation, and trophic factor expression. Researchers have tried to enhance osteogenesis through scaffold modification approaches, including incorporation or coating with mineral, inorganic materials, and herbal extract components. Among them, the incorporation of nanofibers with hyaluronic acid (HA) has been widely used to promote osteogenesis. In this review, the electrospun scaffolds and their modifications used in combination with DPSCs for bone regeneration are discussed.

About the authors

Zahra Safari

Faculty of Dentistry, Tehran University of Medical Sciences

Email: info@benthamscience.net

Seyedeh Sara Aghili

School of Dentistry, Shiraz University of Medical Sciences

Email: info@benthamscience.net

Sahar Hassantash

Faculty of Dentistry, Tehran University of Medical Sciences

Email: info@benthamscience.net

Ehsan Iranmanesh

Neuroscience Research Center, Kerman University of Medical Sciences

Email: info@benthamscience.net

Mehdi Abouali

Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences

Email: info@benthamscience.net

Mobina Bagherianlemraski

Student Research Committee, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran, Mazandaran University of Medical Sciences

Email: info@benthamscience.net

Shabnam Ghasemzadeh

Faculty of Dentistry, Qazvin University of Medical Sciences

Email: info@benthamscience.net

Esmaeel Dadgar

Faculty of Dentistry, Tabriz University of Medical Sciences

Email: info@benthamscience.net

Ghasem Barati

, Stem Cell Technology Research Center

Author for correspondence.
Email: info@benthamscience.net

Ehsan Saburi

Medical Genetics Research Center, Mashhad University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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