Acute Toxicity, Anti-diabetic, and Anti-cancerous Potential of Trillium Govanianum-conjugated Silver Nanoparticles in Balb/c Mice


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Abstract

Background:The current study aimed to develop an economic plant-based therapeutic agent to improve the treatment strategies for diseases at the nano-scale because Cancer and Diabetes mellitus are major concerns in developing countries. Therefore, in vitro and in vivo antidiabetic and anti-cancerous activities of Trillium govanianum conjugated silver nanoparticles were assessed.

Methods:In the current study synthesis of silver nanoparticles using Trillium govanianum and characterization were done using a scanning electron microscope, UV-visible spectrophotometer, and FTIR analysis. The in vitro and in vivo anti-diabetic and anti-cancerous potential (200 mg/kg and 400 mg/kg) were carried out.

Results:It was discovered that Balb/c mice did not show any major alterations during observation of acute oral toxicity when administered orally both TGaqu (1000 mg/kg) and TGAgNPs (1000 mg/kg), and results revealed that 1000 mg/kg is not lethal dose as did not find any abnormalities in epidermal and dermal layers when exposed to TGAgNPs. In vitro studies showed that TGAgNPs could not only inhibit alpha-glucosidase and protein kinases but were also potent against the brine shrimp. Though, a significant reduction in blood glucose levels and significant anti-cancerous effects was recorded when alloxan-treated and CCl4-induced mice were treated with TGAgNPs and TGaqu.

Conclusion:Both in vivo and in vitro studies revealed that TGaqu and TGAgNPs are not toxic at 200 mg/kg, 400 mg/kg, and 1000 mg/kg doses and possess strong anti-diabetic and anti-cancerous effects due to the presence of phyto-constituents. Further, suggesting that green synthesized silver nanoparticles could be used in pharmaceutical industries to develop potent therapeutic agents.

About the authors

Nazia Gulzar

Department of Zoology, Microbial Biotechnology Laboratory, University of Azad Jammu and Kashmir

Email: info@benthamscience.net

Saiqa Andleeb

Department of Zoology, Microbial Biotechnology Laboratory, University of Azad Jammu and Kashmir

Author for correspondence.
Email: info@benthamscience.net

Abida Raza

, PMAS-arid Agriculture University Rawalpindi

Email: info@benthamscience.net

Shaukat Ali

Department of Zoology, Government College University

Email: info@benthamscience.net

Iram Liaqat

Department of Zoology, Government College University

Email: info@benthamscience.net

Sadaf Raja

Bioscience Department, COMSATS University

Email: info@benthamscience.net

Nazish Ali

Department of Zoology, Government College University

Email: info@benthamscience.net

Rida Khan

Department of Zoology, Microbial Biotechnology Laboratory, University of Azad Jammu and Kashmir

Email: info@benthamscience.net

Uzma Awan

Department of Biological Sciences, National University of Medical Sciences (NUMS)

Email: info@benthamscience.net

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