Insights on Quercetin Therapeutic Potential for Neurodegenerative Diseases and its Nano-technological Perspectives


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Abstract

The neurodegeneration process begins in conjunction with the aging of the neurons. It manifests in different parts of the brain as Aβ plaques, neurofibrillary tangles, Lewy bodies, Pick bodies, and other structures, which leads to progressive loss or death of neurons. Quercetin (QC) is a flavonoid compound found in fruits, tea, and other edible plants have antioxidant effects that have been studied from subcellular compartments to tissue levels in the brain. Also, quercetin has been reported to possess a neuroprotective role by decreasing oxidative stress-induced neuronal cell damage. The use of QC for neurodegenerative therapy, the existence of the blood–brain barrier (BBB) remains a significant barrier to improving the clinical effectiveness of the drug, so finding an innovative solution to develop simultaneous BBB-crossing ability of drugs for treating neurodegenerative disorders and improving neurological outcomes is crucial. The nanoparticle formulation of QC is considered beneficial and useful for its delivery through this route for the treatment of neurodegenerative diseases seems necessary. Increased QC accumulation in the brain tissue and more significant improvements in tissue and cellular levels are among the benefits of QC-involved nanostructures.

About the authors

Rajat Goyal

MM College of Pharmacy, Maharishi Markandeshwar (Deemed To be University)

Email: info@benthamscience.net

Garima Mittal

, Panipat Institute of Engineering and Technology

Email: info@benthamscience.net

Suman Khurana

, Panipat Institute of Engineering and Technology

Email: info@benthamscience.net

Neelam Malik

, Panipat Institute of Engineering and Technology

Email: info@benthamscience.net

Vivek Kumar

, Janta College of Pharmacy

Email: info@benthamscience.net

Arti Soni

, Panipat Institute of Engineering and Technology

Author for correspondence.
Email: info@benthamscience.net

Hitesh Chopra

Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences,

Email: info@benthamscience.net

Mohammad Kamal

Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University

Author for correspondence.
Email: info@benthamscience.net

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