A Review of miRNA Regulation in Japanese Encephalitis (JEV) Virus Infection
- Authors: Kumar M.1, Sahoo G.1, Das V.N.2, Singh K.1, Pandey K.2
-
Affiliations:
- Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences
- Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences
- Issue: Vol 25, No 5 (2024)
- Pages: 521-533
- Section: Biotechnology
- URL: https://vietnamjournal.ru/1389-2010/article/view/644833
- DOI: https://doi.org/10.2174/0113892010241606231003102047
- ID: 644833
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Full Text
Abstract
Japanese encephalitis (JE) is a mosquito-borne disease that causes neuronal damage and inflammation of microglia, and in severe cases, it can be fatal. JE infection can resist cellular immune responses and survive in host cells. Japanese encephalitis virus (JEV) infects macrophages and peripheral blood lymphocytes. In addition to regulating biological signaling pathways, microRNAs in cells also influence virus-host interactions. Under certain circumstances, viruses can change microRNA production. These changes affect the replication and spread of the virus. Host miRNAs can contain viral pathogenicity by downregulating the antiviral immune response pathways. Simultaneous profiling of miRNA and messenger RNA (mRNA) could help us detect pathogenic factors, and dual RNA detection is possible. This work highlights important miRNAs involved in human JE infection. In this study, we have shown the important miRNAs that play significant roles in JEV infection. We found that during JEV infection, miRNA-155, miRNA-29b, miRNA-15b, miRNA-146a, miRNA-125b-5p, miRNA-30la, miRNA-19b-3p, and miRNA-124, cause upregulation of human genes whereas miRNA-432, miRNA-370, miRNA- 33a-5p, and miRNA-466d-3p are responsible for downregulation of human genes respectively. Further, these miRNAs are also responsible for the inflammatory effects. Although several other miRNAs critical to the JEV life cycle are yet unknown, there is currently no evidence for the role of miRNAs in persistence.
About the authors
Maneesh Kumar
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences
Email: info@benthamscience.net
Ganesh Sahoo
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences
Author for correspondence.
Email: info@benthamscience.net
Vidya Nand Rabi Das
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences
Email: info@benthamscience.net
Kamal Singh
Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences
Email: info@benthamscience.net
Krishna Pandey
Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences
Email: info@benthamscience.net
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