Lipid Nanocapsule: A Novel Approach to Drug Delivery System Formulation Development

  • Authors: Kumar P.1, Yadav N.2, Chaudhary B.3, Umakanthan S.4, Chattu V.5, Kazmi I.6, Al-Abbasi F.7, Alzarea S.8, Afzal O.9, Altamimi A.10, Gupta G.11, Gupta M.12
  • Affiliations:
    1. , Shri Ram College of Pharmacy
    2. , B. S. Anangpuria Institute of Pharmacy
    3. , Guru Gobind Singh College of Pharmacy
    4. Department of Paraclinical Sciences, Faculty of Medical Sciences,, The University of the West Indies,
    5. Department of OS & OT, Temerty Faculty of Medicine, University of Toronto
    6. Department of Biochemistry, Faculty of Science,, King Abdulaziz University
    7. Department of Biochemistry, Faculty of Science, King Abdulaziz University
    8. Department of Pharmacology, College of Pharmacy,, Jouf University,
    9. Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University
    10. Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University,
    11. School of Pharmacy,, Suresh Gyan Vihar University
    12. School of Pharmacy, Faculty of Medical Sciences,, The University of the West Indies,
  • Issue: Vol 25, No 3 (2024)
  • Pages: 268-284
  • Section: Biotechnology
  • URL: https://vietnamjournal.ru/1389-2010/article/view/644766
  • DOI: https://doi.org/10.2174/1389201024666230523114350
  • ID: 644766

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Abstract

Nanocapsules are polymeric nanoparticles encased in a polymeric coating composed of a predominantly non-ionic surfactant, macromolecules, phospholipids, and an oil core. Lipophilic drugs have been entrapped using various nanocarriers, including lipid cores, likely lipid nanocapsules, solid lipid nanoparticles, and others. A phase inversion temperature approach is used to create lipid nanocapsules. The PEG (polyethyleneglycol) is primarily utilised to produce nanocapsules and is a critical parameter influencing capsule residence time. With their broad drug-loading features, lipid nanocapsules have a distinct advantage in drug delivery systems, such as the capacity to encapsulate hydrophilic or lipophilic pharmaceuticals. Lipid nanocapsules, as detailed in this review, are surface modified, contain target-specific patterns, and have stable physical and chemical properties. Furthermore, lipid nanocapsules have target-specific delivery and are commonly employed as a marker in the diagnosis of numerous illnesses. This review focuses on nanocapsule synthesis, characterisation, and application, which will help understand the unique features of nanocapsules and their application in drug delivery systems.

About the authors

Parveen Kumar

, Shri Ram College of Pharmacy

Email: info@benthamscience.net

Nishant Yadav

, B. S. Anangpuria Institute of Pharmacy

Email: info@benthamscience.net

Benu Chaudhary

, Guru Gobind Singh College of Pharmacy

Email: info@benthamscience.net

Srikant Umakanthan

Department of Paraclinical Sciences, Faculty of Medical Sciences,, The University of the West Indies,

Email: info@benthamscience.net

Vijay Chattu

Department of OS & OT, Temerty Faculty of Medicine, University of Toronto

Email: info@benthamscience.net

Imran Kazmi

Department of Biochemistry, Faculty of Science,, King Abdulaziz University

Email: info@benthamscience.net

Fahad Al-Abbasi

Department of Biochemistry, Faculty of Science, King Abdulaziz University

Email: info@benthamscience.net

Sami Alzarea

Department of Pharmacology, College of Pharmacy,, Jouf University,

Email: info@benthamscience.net

Obaid Afzal

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University

Email: info@benthamscience.net

Abdulmalik Altamimi

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University,

Email: info@benthamscience.net

Gaurav Gupta

School of Pharmacy,, Suresh Gyan Vihar University

Email: info@benthamscience.net

Madan Gupta

School of Pharmacy, Faculty of Medical Sciences,, The University of the West Indies,

Author for correspondence.
Email: info@benthamscience.net

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