The Role of Monosodium Glutamate (MSG) in Epilepsy and other Neurodegenerative Diseases: Phytochemical-based Therapeutic Approa-ches and Mechanisms
- Authors: Singh M.1, Panda S.1
-
Affiliations:
- Institute of Pharmaceutical Research, GLA University
- Issue: Vol 25, No 2 (2024)
- Pages: 213-229
- Section: Biotechnology
- URL: https://vietnamjournal.ru/1389-2010/article/view/644754
- DOI: https://doi.org/10.2174/1389201024666230726161314
- ID: 644754
Cite item
Full Text
Abstract
Epilepsy is a common neurological disease affecting 50 million individuals worldwide, and some forms of epilepsy do not respond to available treatments. Overactivation of the glutamate pathway and excessive entrance of calcium ions into neurons are proposed as the biochemical mechanisms behind epileptic seizures. However, the overactivation of neurons has also been associated with other neurodegenerative diseases (NDDs), such as Alzheimer's, Parkinson's, Huntington's, and multiple sclerosis. The most widely used food ingredient, monosodium glutamate (MSG), increases the level of free glutamate in the brain, putting humans at risk for NDDs and epilepsy. Glutamate is a key neurotransmitter that activates nerve cells. MSG acts on glutamate receptors, specifically NMDA and AMPA receptors, leading to an imbalance between excitatory glutamate and inhibitory GABA neurotransmission. This imbalance can cause hyperexcitability of neurons and lead to epileptic seizures. Overuse of MSG causes neuronal cells to become overexcited, which in turn leads to an increase in the flow of Ca2+ and Na+ ions, mutations, and upregulation in the enzymes superoxide dismutase 1 (SOD-1) and TDP43, all of which contribute to the development of NDDs. While TDP43 and SOD-1 protect cells from damage, a mutation in their genes makes the proteins unprotective and cause neurodegeneration. Yet to what extent mutant SOD1 and TDP43 aggregates contribute to neurotoxicity is generally unknown. This study is focused on neuroprotective herbal medications that can pass the blood-brain barrier and cure MSGinduced NDDs and the factors that influence MSG-induced glutaminergic, astrocyte, and GABAergic neuron abnormalities causing neurodegeneration.
Keywords
About the authors
Mansi Singh
Institute of Pharmaceutical Research, GLA University
Email: info@benthamscience.net
Siva Panda
Institute of Pharmaceutical Research, GLA University
Author for correspondence.
Email: info@benthamscience.net
References
- Zanfirescu, A.; Ungurianu, A.; Tsatsakis, A.M. Nițulescu, G.M.; Kouretas, D.; Veskoukis, A.; Tsoukalas, D.; Engin, A.B.; Aschner, M.; Margină D. A review of the alleged health hazards of monosodium glutamate. Compr. Rev. Food Sci. Food Saf., 2019, 18(4), 1111-1134. doi: 10.1111/1541-4337.12448 PMID: 31920467
- Lau, A.; Tymianski, M. Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch., 2010, 460(2), 525-542. doi: 10.1007/s00424-010-0809-1 PMID: 20229265
- Beyreuther, K.; Biesalski, H.K.; Fernstrom, J.D.; Grimm, P.; Hammes, W.P.; Heinemann, U.; Kempski, O.; Stehle, P.; Steinhart, H.; Walker, R. Consensus meeting: Monosodium glutamate - An update. Eur. J. Clin. Nutr., 2007, 61(3), 304-313. doi: 10.1038/sj.ejcn.1602526 PMID: 16957679
- Magerowski, G.; Giacona, G.; Patriarca, L.; Papadopoulos, K.; Garza-Naveda, P.; Radziejowska, J.; Alonso-Alonso, M. Neurocognitive effects of umami: Association with eating behavior and food choice. Neuropsychopharmacology, 2018, 43(10), 2009-2016. doi: 10.1038/s41386-018-0044-6
- Armstrong, W.R.; Gafita, A.; Zhu, S.; Thin, P.; Nguyen, K.; Alano, R.; Lira, S.; Booker, K.; Gardner, L.; Grogan, T.; Elashoff, D.; Allen-Auerbach, M.; Dahlbom, M.; Czernin, J.; Calais, J. The impact of monosodium glutamate on 68 Ga-PSMA-11 biodistribution in men with prostate cancer: A prospective randomized, controlled imaging study. J. Nucl. Med., 2021, 62(9), 1244-1251. doi: 10.2967/jnumed.120.257931 PMID: 33509974
- Ohgomori, T.; Yamasaki, R.; Takeuchi, H.; Kadomatsu, K.; Kira, J.; Jinno, S. Differential involvement of vesicular and glial glutamate transporters around spinal α-motoneurons in the pathogenesis of SOD1G93A mouse model of amyotrophic lateral sclerosis. Neuroscience, 2017, 356, 114-124. doi: 10.1016/j.neuroscience.2017.05.014 PMID: 28526579
- Farhat, F.; Nofal, S.; Raafat, E.M.; Ali, A.; Ahmed, E. Monosodium glutamate safety, neurotoxicity and some recent studies. Al-Azhar. J. Pharm. Sci., 2021, 64(2), 222-243. doi: 10.21608/ajps.2021.187828
- Kazmi, Z.; Fatima, I.; Perveen, S.; Malik, S.S. Monosodium glutamate: Review on clinical reports. Int. J. Food Prop., 2017, 20(S2), 1807-1815. doi: 10.1080/10942912.2017.1295260
- Hajihasani, M.M.; Soheili, V.; Zirak, M.R.; Sahebkar, A.; Shakeri, A. Natural products as safeguards against monosodium glutamate-induced toxicity. Iran. J. Basic Med. Sci., 2020, 23(4), 416-430. doi: 10.22038/IJBMS.2020.43060.10123 PMID: 32489556
- Traynelis, S.F.; Wollmuth, L.P.; McBain, C.J.; Menniti, F.S.; Vance, K.M.; Ogden, K.K.; Hansen, K.B.; Yuan, H.; Myers, S.J.; Dingledine, R. Glutamate receptor ion channels: Structure, regulation, and function. Pharmacol. Rev., 2010, 62(3), 405-496. doi: 10.1124/pr.109.002451 PMID: 20716669
- Kirchgessner, A. Glutamate in the enteric nervous system. Curr. Opin. Pharmacol., 2001, 1(6), 591-596. doi: 10.1016/S1471-4892(01)00101-1 PMID: 11757814
- Gudiño-Cabrera, G.; Ureña-Guerrero, M.E.; Rivera-Cervantes, M.C.; Feria-Velasco, A.I.; Beas-Zárate, C. Excitotoxicity triggered by neonatal monosodium glutamate treatment and blood-brain barrier function. Arch. Med. Res., 2014, 45(8), 653-659. doi: 10.1016/j.arcmed.2014.11.014 PMID: 25431840
- Chakraborty, S.P. Patho-physiological and toxicological aspects of monosodium glutamate. Toxicol. Mech. Methods, 2019, 29(6), 389-396. doi: 10.1080/15376516.2018.1528649 PMID: 30273089
- Shi, Z.; Yuan, B.; Taylor, A.W.; Dai, Y.; Pan, X.; Gill, T.K.; Wittert, G.A. Monosodium glutamate is related to a higher increase in blood pressure over 5 years: Findings from the Jiangsu Nutrition Study of Chinese adults. J. Hypertens., 2011, 29(5), 846-853. doi: 10.1097/HJH.0b013e328344da8e PMID: 21372742
- Hawkins, R.A. The blood-brain barrier and glutamate. Am. J. Clin. Nutr., 2009, 90(3), 867S-874S. doi: 10.3945/ajcn.2009.27462BB PMID: 19571220
- Mostafa, R. E.; Hassan, A.; Salama, A. Thymol mitigates monosodium glutamate-induced neurotoxic cerebral and hippocampal injury in rats through overexpression of nuclear erythroid 2-related factor 2 signaling pathway as well as altering nuclear factor-kappa b and glial fibrillary acidic protein expression. Open Access Maced. J. Med. Sci., 2021, 9(A), 716-2. doi: 10.3889/oamjms.2021.6170
- Desoky, S.; Abdel-Fattah, A.-R.; Mazen, N. Study of the toxic effectsof monosodium glutamate on the central nervous system.
- Bawaskar, H.; Bawaskar, P.; Bawaskar, P. Chinese restaurant syndrome. Indian J. Crit. Care Med., 2017, 21(1), 49-50. doi: 10.4103/0972-5229.198327 PMID: 28197052
- Fernstrom, J.D. Monosodium glutamate in the diet does not raise brain glutamate concentrations or disrupt brain functions. Ann. Nutr. Metab., 2018, 73(S5), 43-52. doi: 10.1159/000494782
- Torrezan, R.; Malta, A.; Rodrigues, W.N.; dos Santos, A.A.A.; Miranda, R.A.; Moura, E.G.; Lisboa, P.C.; Mathias, P.C. Monosodium L -glutamate‐obesity onset is associated with disruption of central control of the hypothalamic-pituitary-adrenal axis and autonomic nervous system. J. Neuroendocrinol., 2019, 31(6), e12717. doi: 10.1111/jne.12717 PMID: 30929305
- Onaolapo, A.Y.; Onaolapo, O.J. Dietary glutamate and the brain: In the footprints of a Jekyll and Hyde molecule. Neurotoxicology, 2020, 80, 93-104. doi: 10.1016/j.neuro.2020.07.001 PMID: 32687843
- Miśkowiak, B.; Partyka, M. Neonatal treatment with monosodium glutamate (MSG): Structure of the TSH-immunoreactive pituitary cells. Histol. Histopathol., 2000, 15(2), 415-419. doi: 10.14670/HH-15.415 PMID: 10809359
- Mattson, M.P. Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann. N. Y. Acad. Sci., 2008, 1144(1), 97-112. doi: 10.1196/annals.1418.005 PMID: 19076369
- Soares, T.S.; Andreolla, A.P.; Miranda, C.A.; Klöppel, E.; Rodrigues, L.S.; Moraes-Souza, R.Q.; Damasceno, D.C.; Volpato, G.T.; Campos, K.E. Effect of the induction of transgenerational obesity on maternal-fetal parameters. Syst Biol Reprod Med, 2018, 64(1), 51-59. doi: 10.1080/19396368.2017.1410866 PMID: 29227690
- Martínez-Contreras, A.; Huerta, M.; Lopez-Perez, S.; García-Estrada, J.; Luquín, S.; Beas Zárate, C. Astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. J. Neurosci. Res., 2002, 67(2), 200-210. doi: 10.1002/jnr.10093 PMID: 11782964
- Jenner, P.; Dexter, D.T.; Sian, J.; Schapira, A.H.V.; Marsden, C.D. Oxidative stress as a cause of nigral cell death in Parkinsons disease and incidental lewy body disease. Ann. Neurol., 1992, 32(S1), S82-S87. doi: 10.1002/ana.410320714 PMID: 1510385
- Andersen, J.V.; Markussen, K.H.; Jakobsen, E.; Schousboe, A.; Waagepetersen, H.S.; Rosenberg, P.A.; Aldana, B.I. Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration. Neuropharmacology, 2021, 196, 108719. doi: 10.1016/j.neuropharm.2021.108719 PMID: 34273389
- He, K.; Zhao, L.; Daviglus, M.L.; Dyer, A.R.; Van Horn, L.; Garside, D.; Zhu, L.; Guo, D.; Wu, Y.; Zhou, B.; Stamler, J. Association of monosodium glutamate intake with overweight in Chinese adults: The INTERMAP Study. Obesity, 2008, 16(8), 1875-1880. doi: 10.1038/oby.2008.274 PMID: 18497735
- Farombi, E.O.; Onyema, O.O. Monosodium glutamate-induced oxidative damage and genotoxicity in the rat: Modulatory role of vitamin C, vitamin E and quercetin. Hum. Exp. Toxicol., 2006, 25(5), 251-259. doi: 10.1191/0960327106ht621oa PMID: 16758767
- Ureña-Guerrero, M.E.; Orozco-Suárez, S.; López-Pérez, S.J.; Flores-Soto, M.E.; Beas-Zárate, C. Excitotoxic neonatal damage induced by monosodium glutamate reduces several GABAergic markers in the cerebral cortex and hippocampus in adulthood. Int. J. Dev. Neurosci., 2009, 27(8), 845-855. doi: 10.1016/j.ijdevneu.2009.07.011 PMID: 19733649
- Rosa, S.G.; Quines, C.B.; Stangherlin, E.C.; Nogueira, C.W. Diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal BDNF-Akt pathway and uptake of GABA and serotonin neurotransmitters. Physiol. Behav., 2016, 155, 1-8. doi: 10.1016/j.physbeh.2015.11.038 PMID: 26657020
- Bolaños, J.P.; Almeida, A.; Stewart, V.; Peuchen, S.; Land, J.M.; Clark, J.B.; Heales, S.J.R. Nitric oxide-mediated mitochondrial damage in the brain: Mechanisms and implications for neurodegenerative diseases. J. Neurochem., 1997, 68(6), 2227-2240. doi: 10.1046/j.1471-4159.1997.68062227.x PMID: 9166714
- Benbow, T.; Ekbatan, M.R.; Wang, G.H.Y.; Teja, F.; Exposto, F.G.; Svensson, P.; Cairns, B.E. Systemic administration of monosodium glutamate induces sexually dimorphic headache- and nausea-like behaviours in rats. Pain, 2022, 163(9), 1838-1853. doi: 10.1097/j.pain.0000000000002592 PMID: 35404557
- Kumar, P.; Kraal, A.Z.; Prawdzik, A.M.; Ringold, A.E.; Ellingrod, V. Dietary glutamic acid, obesity, and depressive symptoms in patients with schizophrenia. Front. Psychiatry, 2021, 11, 620097. doi: 10.3389/fpsyt.2020.620097 PMID: 33551881
- Vitor-de-Lima, S.M.; Medeiros, L.B.; Benevides, R.D.L.; dos Santos, C.N.; Lima da Silva, N.O.; Guedes, R.C.A. Monosodium glutamate and treadmill exercise: Anxiety-like behavior and spreading depression features in young adult rats. Nutr. Neurosci., 2019, 22(6), 435-443. doi: 10.1080/1028415X.2017.1398301 PMID: 29125056
- Biney, R.P.; Djankpa, F.T.; Osei, S.A.; Egbenya, D.L.; Aboagye, B.; Karikari, A.A.; Ussif, A.; Wiafe, G.A.; Nuertey, D. Effects of in utero exposure to monosodium glutamate on locomotion, anxiety, depression, memory and KCC2 expression in offspring. Int. J. Dev. Neurosci., 2022, 82(1), 50-62. doi: 10.1002/jdn.10158 PMID: 34755371
- Bahadoran, Z.; Mirmiran, P.; Ghasemi, A. Monosodium glutamate (MSG)-Induced animal model of Type 2 diabetes. Methods Mol. Biol., 2019, 1916, 49-65. doi: 10.1007/978-1-4939-8994-2_3
- Fuchsberger, T.; Yuste, R.; Martinez-Bellver, S.; Blanco-Gandia, M.C.; Torres-Cuevas, I.; Blasco-Serra, A.; Arango, R.; Miñarro, J.; Rodríguez-Arias, M.; Teruel-Marti, V.; Lloret, A.; Viña, J. Oral monosodium glutamate administration causes early onset of alzheimers disease-like pathophysiology in APP/PS1 mice. J. Alzheimers Dis., 2019, 72(3), 957-975. doi: 10.3233/JAD-190274 PMID: 31658055
- Demirkapu, M.J. Yananlı H.R.; Akşahin, E.; Karabiber, C.; Günay, P.; Kekilli, A.; Topkara, B. The effect of oral administration of monosodium glutamate on epileptogenesis in infant rats. Epileptic Disord., 2020, 22(2), 195-201. doi: 10.1684/epd.2020.1156 PMID: 32310135
- Kumar, M.; Kumar, A.; Sindhu, R.K.; Kushwah, A.S. Arbutin attenuates monosodium L-glutamate induced neurotoxicity and cognitive dysfunction in rats. Neurochem. Int., 2021, 151, 105217. doi: 10.1016/j.neuint.2021.105217 PMID: 34710534
- Gürgen, S.G. Sayın, O.; Çeti̇n, F.; Sarsmaz, H.Y.; Yazıcı G.N.; Umur, N.; Yücel, A.T. The effect of monosodium glutamate on neuronal signaling molecules in the hippocampus and the neuroprotective effects of omega-3 fatty acids. ACS Chem. Neurosci., 2021, 12(16), 3028-3037. doi: 10.1021/acschemneuro.1c00308 PMID: 34328736
- ATEF. H.; EL-MORSI, D.A.; EL-SHAFEY, M.; AL-MONIEM SAEED, A.A. Monosodium glutamate induced hepatotoxicity and oxidative stress: pathophysiological, biochemical and electron microscopic study. Med. J. Cairo Univ., 2019, 87(March), 397-406. doi: 10.21608/mjcu.2019.52361
- Bölükbaş F.; Öznurlu, Y. Determining the effects of in ovo administration of monosodium glutamate on the embryonic development of brain in chickens. Neurotoxicology, 2023, 94, 87-97. doi: 10.1016/j.neuro.2022.11.009 PMID: 36400230
- Kraal, A.Z.; Arvanitis, N.R.; Jaeger, A.P.; Ellingrod, V.L. Could dietary glutamate play a role in psychiatric distress? Neuropsychobiology, 2020, 79(1), 13-19. doi: 10.1159/000496294 PMID: 30699435
- Suthar, S.K.; Lee, S.Y. The role of superoxide dismutase 1 in amyotrophic lateral sclerosis: Identification of signaling pathways, regulators, molecular interaction networks, and biological functions through bioinformatics. Brain Sci., 2023, 13(1), 151. doi: 10.3390/brainsci13010151 PMID: 36672132
- Liao, R.; Wood, T.R.; Nance, E. Superoxide dismutase reduces monosodium glutamate-induced injury in an organotypic whole hemisphere brain slice model of excitotoxicity. J. Biol. Eng., 2020, 14(1), 3. doi: 10.1186/s13036-020-0226-8 PMID: 32042309
- Zhao, S.; Chen, F.; Yin, Q.; Wang, D.; Han, W.; Zhang, Y. Reactive oxygen species interact with NLRP3 inflammasomes and are involved in the inflammation of sepsis: From mechanism to treatment of progression. Front. Physiol., 2020, 11, 571810. doi: 10.3389/fphys.2020.571810 PMID: 33324236
- Pirie, E.; Oh, C.; Zhang, X.; Han, X.; Cieplak, P.; Scott, H.R.; Deal, A.K.; Ghatak, S.; Martinez, F.J.; Yeo, G.W.; Yates, J.R., III; Nakamura, T.; Lipton, S.A. S-nitrosylated TDP-43 triggers aggregation, cell-to-cell spread, and neurotoxicity in hiPSCs and in vivo models of ALS/FTD. Proc. Natl. Acad. Sci., 2021, 118(11), e2021368118. doi: 10.1073/pnas.2021368118 PMID: 33692125
- Trist, B.G.; Hilton, J.B.; Hare, D.J.; Crouch, P.J.; Double, K.L. Superoxide dismutase 1 in health and disease: How a frontline antioxidant becomes neurotoxic. Angew. Chem. Int. Ed., 2021, 60(17), 9215-9246. doi: 10.1002/anie.202000451 PMID: 32144830
- Kabashi, E.; Valdmanis, P.N.; Dion, P.; Rouleau, G.A. Oxidized/misfolded superoxide dismutase-1: The cause of all amyotrophic lateral sclerosis? Ann. Neurol., 2007, 62(6), 553-559. doi: 10.1002/ana.21319 PMID: 18074357
- Meneses, A.; Koga, S.; OLeary, J.; Dickson, D.W.; Bu, G.; Zhao, N. TDP-43 pathology in alzheimers disease. Mol. Neurodegener., 2021, 16(1), 84. doi: 10.1186/s13024-021-00503-x PMID: 34930382
- Chen, S.; Xu, D.; Fan, L.; Fang, Z.; Wang, X.; Li, M. Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy. Front. Mol. Neurosci., 2022, 14, 797253. doi: 10.3389/fnmol.2021.797253 PMID: 35069111
- Jo, M.; Lee, S.; Jeon, Y.M.; Kim, S.; Kwon, Y.; Kim, H.J. The role of TDP-43 propagation in neurodegenerative diseases: Integrating insights from clinical and experimental studies. Exp. Mol. Med., 2020, 52(10), 1652-1662. doi: 10.1038/s12276-020-00513-7 PMID: 33051572
- Sarlo, G.L.; Holton, K.F. Brain concentrations of glutamate and GABA in human epilepsy: A review. Seizure, 2021, 91, 213-227. doi: 10.1016/j.seizure.2021.06.028 PMID: 34233236
- Davis, K.A.; Nanga, R.P.R.; Das, S.; Chen, S.H.; Hadar, P.N.; Pollard, J.R.; Lucas, T.H.; Shinohara, R.T.; Litt, B.; Hariharan, H.; Elliott, M.A.; Detre, J.A.; Reddy, R. Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy. Sci. Transl. Med., 2015, 7(309), 309ra161. doi: 10.1126/scitranslmed.aaa7095 PMID: 26468323
- Barker-Haliski, M.; White, H.S. Glutamatergic mechanisms associated with seizures and epilepsy. Cold Spring Harb. Perspect. Med., 2015, 5(8), a022863. doi: 10.1101/cshperspect.a022863 PMID: 26101204
- Yuen, T.I.; Morokoff, A.P.; Bjorksten, A.; DAbaco, G.; Paradiso, L.; Finch, S.; Wong, D.; Reid, C.A.; Powell, K.L.; Drummond, K.J.; Rosenthal, M.A.; Kaye, A.H.; OBrien, T.J. Glutamate is associated with a higher risk of seizures in patients with gliomas. Neurology, 2012, 79(9), 883-889. doi: 10.1212/WNL.0b013e318266fa89 PMID: 22843268
- Ranpariya, V.L.; Parmar, S.K.; Sheth, N.R.; Chandrashekhar, V.M. Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats. Pharm. Biol., 2011, 49(7), 696-701. doi: 10.3109/13880209.2010.540249 PMID: 21599496
- Prasansuklab, A.; Tencomnao, T. Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate. BMC Complement. Altern. Med., 2018, 18(1), 278. doi: 10.1186/s12906-018-2340-4 PMID: 30326896
- Friedli, M.J.; Inestrosa, N.C. Huperzine a and its neuroprotective molecular signaling in alzheimers disease. Molecules, 2021, 26(21), 6531. doi: 10.3390/molecules26216531 PMID: 34770940
- Shoaib, A.; Siddiqui, H.H.; Dixit, R.K.; Siddiqui, S.; Deen, B.; Khan, A.; Alrokayan, S.H.; Khan, H.A.; Ahmad, P. Neuroprotective effects of dried tubers of aconitum napellus. Plants, 2020, 9(3), 356. doi: 10.3390/plants9030356 PMID: 32168878
- Prasansuklab, A.; Meemon, K.; Sobhon, P.; Tencomnao, T. Ethanolic extract of Streblus asper leaves protects against glutamate-induced toxicity in HT22 hippocampal neuronal cells and extends lifespan of Caenorhabditis elegans. BMC Complement. Altern. Med., 2017, 17(1), 551. doi: 10.1186/s12906-017-2050-3 PMID: 29282044
- Pan, Y.; Wu, D.; Liang, H.; Tang, G.; Fan, C.; Shi, L.; Ye, W.; Li, M. Total saponins of panax notoginseng activate Akt/mTOR pathway and exhibit neuroprotection in vitro and in vivo against ischemic damage. Chin. J. Integr. Med., 2022, 28(5), 410-418. doi: 10.1007/s11655-021-3454-y PMID: 34581940
- Yang, W.; Ip, S.P.; Liu, L.; Xian, Y.F.; Lin, Z.X. Uncaria rhynchophylla and its major constituents on central nervous system: A review on their pharmacological actions. Curr. Vasc. Pharmacol., 2020, 18(4), 346-357. doi: 10.2174/1570161117666190704092841 PMID: 31272356
- Li, M.; Zhang, X.; Cui, L.; Yang, R.; Wang, L.; Liu, L.; Du, W. The neuroprotection of oxymatrine in cerebral ischemia/reperfusion is related to nuclear factor erythroid 2-related factor 2 (nrf2)-mediated antioxidant response: Role of nrf2 and hemeoxygenase-1 expression. Biol. Pharm. Bull., 2011, 34(5), 595-601. doi: 10.1248/bpb.34.595 PMID: 21532144
- Subedi, L.; Gaire, B.P. Tanshinone IIA: A phytochemical as a promising drug candidate for neurodegenerative diseases. Pharmacol. Res., 2021, 169, 105661. doi: 10.1016/j.phrs.2021.105661 PMID: 33971269
- Sukprasansap, M.; Chanvorachote, P.; Tencomnao, T. Cleistocalyx nervosum var. paniala berry fruit protects neurotoxicity against endoplasmic reticulum stress-induced apoptosis. Food Chem. Toxicol., 2017, 103, 279-288. doi: 10.1016/j.fct.2017.03.025 PMID: 28315776
- Luine, V.N. Estradiol and cognitive function: Past, present and future. Horm. Behav., 2014, 66(4), 602-618. doi: 10.1016/j.yhbeh.2014.08.011 PMID: 25205317
- Chuang, K.A.; Li, M.H.; Lin, N.H.; Chang, C.H.; Lu, I.H.; Pan, I.H.; Takahashi, T.; Perng, M.D.; Wen, S.F. Rhinacanthin C alleviates amyloid- β fibrils toxicity on neurons and attenuates neuroinflammation triggered by LPS, amyloid- β and interferon- γ in glial cells. Oxid. Med. Cell. Longev., 2017, 2017, 1-18. doi: 10.1155/2017/5414297 PMID: 29181126
- Brimson, J.M.; Prasanth, M.I.; Plaingam, W.; Tencomnao, T. Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans. J. Tradit. Complement. Med., 2020, 10(5), 460-470. doi: 10.1016/j.jtcme.2019.10.001 PMID: 32953562
- Li, S.; Wu, C.; Zhu, L.; Gao, J.; Fang, J.; Li, D.; Fu, M.; Liang, R.; Wang, L.; Cheng, M.; Yang, H. By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke. Molecules, 2012, 17(11), 13403-13423. doi: 10.3390/molecules171113403 PMID: 23143152
- Lin, Y.E.; Lin, C.H.; Ho, E.P.; Ke, Y.C.; Petridi, S.; Elliott, C.J.H.; Sheen, L.Y.; Chien, C.T. Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinsons disease. eLife, 2021, 10, e73753. doi: 10.7554/eLife.73753 PMID: 34779396
- Lee, S.E.; Kim, J.H.; Lim, C.; Cho, S. Neuroprotective effect of Angelica gigas root in a mouse model of ischemic brain injury through MAPK signaling pathway regulation. Chin. Med., 2020, 15(1), 101. doi: 10.1186/s13020-020-00383-1 PMID: 32983252
- Liu, J.; Liu, S.; Hao, L.; Liu, F.; Mu, S.; Wang, T. Uncovering the mechanism of Radix Paeoniae Alba in the treatment of restless legs syndrome based on network pharmacology and molecular docking. Medicine, 2022, 101(46), e31791. doi: 10.1097/MD.0000000000031791 PMID: 36401463
- Nayak, S.; Nayanatara, A.K.; Hegde, A.; Kini, D. R.; Blossom, V.; Poojary, R. Neuroprotective role of Allium cepa and Allium sativum on Hippocampus, striatum and Cerebral cortex in Wistar rats. Res. J. Pharma. Technol., 2021, (May), 2406-2411. doi: 10.52711/0974-360X.2021.00424
- Chethana, G.S.; Venkatesh, H.; Gopinath, S.M. Review on clerodendrum inerme. J. Pharmaceut. Scie. Innov., 2013, 2(2), 38-40. doi: 10.7897/2277-4572.02220
- Ban, J.Y.; Cho, S.O.; Choi, S.H.; Ju, H.S.; Kim, J.Y.; Bae, K.; Song, K.S.; Seong, Y.H. Neuroprotective effect of Smilacis chinae rhizome on NMDA-induced neurotoxicity in vitro and focal cerebral ischemia in vivo. J. Pharmacol. Sci., 2008, 106(1), 68-77. doi: 10.1254/jphs.FP0071206 PMID: 18202548
- Xu, J.; Wang, F.; Guo, J.; Xu, C.; Cao, Y.; Fang, Z.; Wang, Q. Pharmacological mechanisms underlying the neuroprotective effects of Alpinia oxyphylla Miq. on Alzheimers disease. Int. J. Mol. Sci., 2020, 21(6), 2071. doi: 10.3390/ijms21062071 PMID: 32197305
- Lima Pereira, É.P.; Santos Souza, C.; Amparo, J.; Short Ferreira, R.; Nuñez-Figueredo, Y.; Gonzaga Fernandez, L.; Ribeiro, P.R.; Braga-de-Souza, S.; Amaral da Silva, V.D.; Lima Costa, S. Amburana cearensis seed extract protects brain mitochondria from oxidative stress and cerebellar cells from excitotoxicity induced by glutamate. J. Ethnopharmacol., 2017, 209, 157-166. doi: 10.1016/j.jep.2017.07.017 PMID: 28712890
- Ren, Y.; Frank, T.; Meyer, G.; Lei, J.; Grebenc, J.R.; Slaughter, R.; Gao, Y.G.; Kinghorn, A.D. Potential benefits of black chokeberry (aronia melanocarpa) fruits and their constituents in Improving Human Health. Molecules, 2022, 27(22), 7823. doi: 10.3390/molecules27227823 PMID: 36431924
- Gomaa, A.A.; Makboul, R.M.; Al-Mokhtar, M.A.; Nicola, M.A. Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines. Biomed. Pharmacother., 2019, 109, 281-292. doi: 10.1016/j.biopha.2018.10.056 PMID: 30396086
- Komaki, A.; Moradkhani, S.; Salehi, I.; Abdolmaleki, S. Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats. Anc. Sci. Life, 2015, 34(3), 156-161. doi: 10.4103/0257-7941.157160 PMID: 26120230
- Zhang, Y.L.; Liu, Y.; Kang, X.P.; Dou, C.Y.; Zhuo, R.G.; Huang, S.Q.; Peng, L.; Wen, L. Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinsons disease. Neuropharmacology, 2018, 131, 223-237. doi: 10.1016/j.neuropharm.2017.12.012 PMID: 29241654
- Kim, H.N.; Jang, J.Y.; Choi, B.T. A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neurons. Anat. Cell Biol., 2015, 48(2), 95-103. doi: 10.5115/acb.2015.48.2.95 PMID: 26140220
- Jang, J.H.; Son, Y.; Kang, S.S.; Bae, C.S.; Kim, J.C.; Kim, S.H.; Shin, T.; Moon, C. Neuropharmacological potential of gastrodia elata blume and its components. Evid. Based Complement. Alternat. Med., 2015, 2015, 1-14. doi: 10.1155/2015/309261 PMID: 26543487
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