The Astonishing Accomplishment of Biological Drug Delivery using Lipid Nanoparticles: An Ubiquitous Review


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Abstract

:Biotech drugs, including proteins, hormones, enzymes, DNA/RNA therapies, and cell-based treatments, are gaining popularity due to their effectiveness. However, effective delivery systems are needed to overcome administration challenges. Lipid nanoparticles (LNPs) have emerged as promising carriers for various therapies. LNPs are biocompatible, less likely to cause adverse reactions, and can stabilize delicate biological drugs, enhancing their stability and solubility. Scalable and cost-effective manufacturing processes make LNPs suitable for largescale production. Despite recent research efforts, challenges in stability, toxicity, and regulatory concerns have limited the commercial availability of LNP-based products. This review explores the applications, administration routes, challenges, and future directions of LNPs in delivering biopharmaceuticals.

About the authors

Devesh Kapoor

Department of Pharmaceutical Technology, Dr. Dayaram Patel Pharmacy College

Email: info@benthamscience.net

Shirisha Chilkapalli

Department of Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University

Email: info@benthamscience.net

Bhupendra Prajapati

Department of Pharmaceutical Technology, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University

Author for correspondence.
Email: info@benthamscience.net

Paul Rodriques

Department of Pharmaceutical Technology, Krishna School of Emerging Technology and Applied Research

Email: info@benthamscience.net

Ravish Patel

Department of Pharmaceutical Technology, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology

Email: info@benthamscience.net

Sudarshan Singh

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University

Author for correspondence.
Email: info@benthamscience.net

Sankha Bhattacharya

Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM’S NMIMS School of Pharmacy and Technology Management

Email: info@benthamscience.net

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