Therapeutic Assessment of Crystalloid Fluid Resuscitation in Experimental Military Injury

  • Authors: Li M.1, Wang F.2, Chen X.3, Cao S.4, Zhou Y.5, Ou X.6, He M.6, Cai H.7, Dai W.8, Yuan D.9, Zeng L.6, Ni L.10, Li J.11, Zhou Y.11, Liang W.12, Xie X.6, Zhou J.8
  • Affiliations:
    1. Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine,, Sichuan University
    2. Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University
    3. Department of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University
    4. Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University
    5. , Shanghai High-Tech United Bio-Technological R&D Co., Ltd,
    6. Department of Critical Care Medicine, West China Hospital,, Sichuan University
    7. Department of Traffic Injury Prevention Research Office, Daping Hospital,, Army Medical University
    8. Daping Hospital & Research Institute of Surgery, Army Medical Center of the People’s Liberation Army (PLA), Army Medical University
    9. Daping Hospital & Research Institute of Surgery, Army Medical Center of the People’s Liberation Army (PLA), Army Medical University,
    10. Department of Critical Care Medicine, West China Hospital,, Sichuan University,
    11. Department of Clinical Laboratory,, The 945th Hospital of The Joint Logistic Support Force of PLA
    12. Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, SichuanUniversity
  • Issue: Vol 25, No 1 (2024)
  • Pages: 93-101
  • Section: Biotechnology
  • URL: https://vietnamjournal.ru/1389-2010/article/view/644342
  • DOI: https://doi.org/10.2174/1389201024666230330100423
  • ID: 644342

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Full Text

Abstract

Background:A significant part of blast injury is accompanied by hemorrhagic shock (BS), while research on its fluid resuscitation strategies have not been reported. Although blood products are usually recommended in most resuscitation cases, they are less available in certain conditions. To this end, here, we focused on a widely used and more accessible fluid type- crystalloid fluid, in BS treatment.

Methods:We conducted studies in rats comparing the therapeutic effects of 3 different crystalloid solutions at different time points after BS, and explored the underlying mechanisms. Generally, the survival rates gradually dropped along with the time when fluid resuscitation was given.

Results:Among different types of solution, the hypertonic saline (HS) group showed the highest survival rates. The lactated Ringer’s solution (LR) only displayed lifesaving effect at 0.5 h resuscitation time point. Moreover, it is worth noting that the survival rates of the normal saline (NS) group at all the time points were lower than the non-treatment control. Mechanism study in rats indicated that the therapeutic differences may be caused by varied degrees of pulmonary edema and inflammatory responses under different crystalloid fluid resuscitation.

Conclusion:In conclusion, we assessed the effects and investigated the mechanisms of different crystalloid fluid resuscitation strategies for BS for the first time, which potentially contributes to the establishment of guidance for crystalloid fluid resuscitation of BS patients.

About the authors

Manrui Li

Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine,, Sichuan University

Email: info@benthamscience.net

Feng Wang

Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University

Email: info@benthamscience.net

Xiameng Chen

Department of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University

Email: info@benthamscience.net

Shuqiang Cao

Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University

Email: info@benthamscience.net

Yizhi Zhou

, Shanghai High-Tech United Bio-Technological R&D Co., Ltd,

Email: info@benthamscience.net

Xiaofeng Ou

Department of Critical Care Medicine, West China Hospital,, Sichuan University

Email: info@benthamscience.net

Min He

Department of Critical Care Medicine, West China Hospital,, Sichuan University

Email: info@benthamscience.net

Hanzi Cai

Department of Traffic Injury Prevention Research Office, Daping Hospital,, Army Medical University

Email: info@benthamscience.net

Wei Dai

Daping Hospital & Research Institute of Surgery, Army Medical Center of the People’s Liberation Army (PLA), Army Medical University

Email: info@benthamscience.net

Dangfeng Yuan

Daping Hospital & Research Institute of Surgery, Army Medical Center of the People’s Liberation Army (PLA), Army Medical University,

Email: info@benthamscience.net

Li Zeng

Department of Critical Care Medicine, West China Hospital,, Sichuan University

Email: info@benthamscience.net

Lei Ni

Department of Critical Care Medicine, West China Hospital,, Sichuan University,

Email: info@benthamscience.net

Jingyong Li

Department of Clinical Laboratory,, The 945th Hospital of The Joint Logistic Support Force of PLA

Email: info@benthamscience.net

Yang Zhou

Department of Clinical Laboratory,, The 945th Hospital of The Joint Logistic Support Force of PLA

Email: info@benthamscience.net

Weibo Liang

Department of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, SichuanUniversity

Author for correspondence.
Email: info@benthamscience.net

Xiaoqi Xie

Department of Critical Care Medicine, West China Hospital,, Sichuan University

Author for correspondence.
Email: info@benthamscience.net

Jihong Zhou

Daping Hospital & Research Institute of Surgery, Army Medical Center of the People’s Liberation Army (PLA), Army Medical University

Author for correspondence.
Email: info@benthamscience.net

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