Expanded Therapeutic Applications of Holarrhena Antidysenterica: A Review


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Background:The use of medicinal plants as a rich resource of therapeutic agents in the treatment and prevention of diseases & ailments has been recognized for millennia and is highly regarded worldwide. Holarrhena antidysenterica (H. antidysenterica), also called kurchi, or kutaj, has been utilized since the dawn of time, Apocynaceae member, also known as H. pubescens, is praised for the medicinal uses of its stem bark, leaves, and seeds in Ayurveda.

Objective:The study concentrated on aggregate information regarding H. antidysenterica's therapeutic effects. The purpose of the study was to compile pharmacological activities of H. antidysentrica seeds.

Methods:Regardless of its broad variety of biological and possible therapeutic uses, there has been increasing concern regarding the use of H. antidysenterica.

Result:Various phytochemicals have been extracted from H. antidysenterica in recent years and have demonstrated typical pharmacological properties, including antibacterial, anti-diarrhoeal, anti-diabetic, anti-oxidant, anti-urolithic, and anti-inflammatory activity.

Conclusion:This review paper investigated the in-depth description and pharmacological properties of the plant, which produced significant findings on the chemical components present and also verified the traditionally claimed properties associated with the plant.

Sobre autores

Ruchi Tiwari

, PSIT-Pranveer Singh Institute of Technology (Pharmacy)

Email: info@benthamscience.net

Charul Khatri

, PSIT-Pranveer Singh Institute of Technology (Pharmacy)

Email: info@benthamscience.net

Lalit Tyagi

, Lloyd Institute of Management and Technology

Email: info@benthamscience.net

Gaurav Tiwari

, PSIT-Pranveer Singh Institute of Technology (Pharmacy)

Autor responsável pela correspondência
Email: info@benthamscience.net

Bibliografia

  1. Dey, A.; De, J.N. Ethnobotanical survey of Purulia district, West Bengal, India for medicinal plants used against gastrointestinal disorders. J. Ethnopharmacol., 2012, 143(1), 68-80. doi: 10.1016/j.jep.2012.05.064 PMID: 22721882
  2. Chakraborty, A.; Brantner, A.H. Antibacterial steroid alkaloids from the stem bark of Holarrhena pubescens. J. Ethnopharmacol., 1999, 68(1-3), 339-344. doi: 10.1016/S0378-8741(99)00119-1 PMID: 10624899
  3. Chusri, S.; Villanueva, I.; Voravuthikunchai, S.P.; Davies, J. Enhancing antibiotic activity: A strategy to control Acinetobacter infections. J. Antimicrob. Chemother., 2009, 64(6), 1203-1211. doi: 10.1093/jac/dkp381 PMID: 19861335
  4. Tambekar, D.H.; Dahikar, S.B. Antibacterial activity of some Indian ayurvedic preparations against enteric bacterial pathogens. J. Adv. Pharm. Technol. Res., 2011, 2(1), 24-29. doi: 10.4103/2231-4040.79801 PMID: 22171288
  5. Sharma, U.; Velpandian, T.; Sharma, P.; Singh, S. Evaluation of anti-leishmanial activity of selected Indian plants known to have antimicrobial properties. Parasitol. Res., 2009, 105(5), 1287-1293. doi: 10.1007/s00436-009-1554-2 PMID: 19593584
  6. Mahato, S.; Mehta, A.; Roy, S. Studies on antibacterial effects of bark, seed and callus extracts of Holarrhena antidysenterica wall. Indian J. Exp. Biol., 2013, 8(2), 717-721.
  7. Jamadagni, P.; Pawar, S.; Jamadagni, S.; Chougule, S.; Gaidhani, S.; Murthy, S.N. Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective. Pharmacogn. Rev., 2017, 11(22), 141-144. doi: 10.4103/phrev.phrev_31_16 PMID: 28989249
  8. Mrinal, S.; Navjeet, S.A. Review on pharmacological aspects of Holarrhena antidysenterica. Sch. Acad. J. Pharm., 2018, 7(12), 488-492. doi: 10.21276/sajp.2018.7.12.5
  9. Gopinath, G.; Thirumal, M.; Kumar, P.R. Holarrhena antidysenterica Linn. – A Review. Res. J. Pharm. Technol., 2020, 13(4), 2013-2018. doi: 10.5958/0974-360X.2020.00362.5
  10. Banadawane, D.; Patil, M.; Jadhav, S. Flavonoid rich fraction of Holarrhena antidysenterica Leaves. Attenuate hyperglycemia by ameliorating hyperlipidemia and oxidative stress in type 2 diabetes in rats. Biomed. J. Sci. Tech. Res., 2019, 16(2), 11892-11902. doi: 10.26717/BJSTR.2019.16.002821
  11. Sinha, S.; Sharma, A.; Reddy, P.H.; Rathi, B.; Prasad, N.V.S.R.K.; Vashishtha, A. Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): A comprehensive review. J. Pharm. Res., 2013, 6(4), 488-492. doi: 10.1016/j.jopr.2013.04.004
  12. Pradeepa, R.; Mohan, V. The changing scenario of the diabetes epidemic: Implications for India. Indian J. Med. Res., 2002, 116, 121-132. PMID: 12674825
  13. Bhuiyan, M.M.R.; Bhuiya, N.M.M.A.; Hasan, M.N.; Nahar, U.J. In vivo and in silico evaluation of antinociceptive activities of seed extract from the Holarrhena antidysenterica plant. Heliyon, 2020, 6(5), e03962. doi: 10.1016/j.heliyon.2020.e03962 PMID: 32426548
  14. Ali, K.M.; Chatterjee, K.; De, D.; Jana, K.; Bera, T.K.; Ghosh, D. Inhibitory effect of hydro-methanolic extract of seed of Holarrhena antidysenterica on alpha-glucosidase activity and postprandial blood glucose level in normoglycemic rat. J. Ethnopharmacol., 2011, 135(1), 194-196. doi: 10.1016/j.jep.2011.02.034 PMID: 21385604
  15. Keshri, U.P.D. Antidiabetic efficacy of ethanolic extract of Holarrhena antidysenterica seeds linn STZ induced diabetic rats and influence on certain biochemical parameters. J. Drug Deliv. Ther., 2012, 2(4), 159-162. doi: 10.22270/jddt.v2i4.187
  16. Sharma, D.K.; Gupta, V.K.; Kumar, S.; Joshi, V.; Mandal, R.S.K.; Prakash, A.G.B.; Singh, M. Evaluation of antidiarrheal activity of ethanolic extract of Holarrhena antidysenterica seeds in rats. Vet. World, 2015, 8(12), 1392-1395. doi: 10.14202/vetworld.2015.1392-1395 PMID: 27047049
  17. Yakub, Sheikh; Vinod Kathait; Rajesh Kumar; Kumar, R. Computation of in-vivo antidiabetic activity of Holarrhena antidysenterica seeds extracts in STZ induced diabetic Rats. Pharmaceuti. Biosci. J., 2013, 1, 11-17. doi: 10.20510/ukjpb/1/i1/91106
  18. Kumar, S.; Yadav, A. Comparative study of hypoglycaemic effect of Holarrhena antidysenterica seeds and glibenclamide in experimentally induced diabetes mellitus in albino rats. Biomed. Pharmacol. J., 2015, 8(1), 477-483. doi: 10.13005/bpj/637
  19. Murugan, S.; Purusothaman, D.; Richard, E.J.; Chalichem, N.S.S.; Bethapudi, B.; Chandrasekaran, P.R.; Velusami, C.C.; D’Souza, P.; Mundkinajeddu, D. Anti-diarrhoeal activity of a polyherbal formulation in rats and elucidation of its cellular mechanisms. Avicenna J. Phytomed., 2020, 10(4), 417-427. doi: 10.22038/AJP.2019.14339 PMID: 32850298
  20. Kavitha, D.; Shilpa, P.N.; Devaraj, S.N. Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena antidysenterica WALL. Indian J. Exp. Biol., 2004, 42(6), 589-594. PMID: 15260110
  21. Singh, V.K.; Ali, Z.A.; Siddiqui, M.K. Medicinal Plants Used by the Forest Ethnics of Gorakhpur District (Uttar Pradesh), India. Int. J. Pharmacog., 1997, 35(3), 194-206. doi: 10.1076/phbi.35.3.194.13298
  22. Bhusal, A.; Jamarkattel, N.; Shrestha, A.; Lamsal, N.K.; Shakya, S.; Rajbhandari, S. Evaluation of antioxidative and antidiabetic activity of bark of holarrhena pubescens wall. J. Clin. Diagn. Res., 2014, 8(9), HC05-HC08. doi: 10.7860/JCDR/2014/7803.4863 PMID: 25386454
  23. Ganapathy, P.S.; Ramachandra, Y.L.; Rai, S.P. In vitro antioxidant activity of Holarrhena antidysenterica Wall. Methanolic leaf extract. J. Basic Clin. Pharm., 2011, 2(4), 175-178. PMID: 24826020
  24. Anita, P.; Balan, I.N.; Ethiraj, S.; Madan Kumar, P.D.; Sivasamy, S. In vitro antibacterial activity of Camellia sinensis extract against cariogenic microorganisms. J. Basic Clin. Pharm., 2015, 6(1), 35-39. doi: 10.4103/0976-0105.145777 PMID: 25538470
  25. Zihadi, M.; Rahman, M.; Talukder, S.; Hasan, M.; Nahar, S.; Sikder, M. Antibacterial efficacy of ethanolic extract of Camellia sinensis and Azadirachta indica leaves on methicillin-resistant Staphylococcus aureus and shiga-toxigenic Escherichia coli. J. Adv. Vet. Anim. Res., 2019, 6(2), 247-252. doi: 10.5455/javar.2019.f340 PMID: 31453199
  26. Panda, S.K.; Padhi, L.; Leyssen, P.; Liu, M.; Neyts, J.; Luyten, W. Antimicrobial, anthelmintic, and antiviral activity of plants traditionally used for treating infectious disease in the Similipal biosphere reserve, Odisha, India. Front. Pharmacol., 2017, 8, 658. doi: 10.3389/fphar.2017.00658 PMID: 29109684
  27. Shah, S.A.; Usmanghani, K.; Akhtar, N.; Asif, H.M.; Akram, M.; Ahmed, K.; Shaheen, G.; Shamim, T.; Rehman, R.; Ahmad, A.; Sumreen, L. Monograph of Holarrhena antidysenterica (linn.) wall. Phytomedicine, 2010, 2(4), 345-348. doi: 10.5138/ijpm.2010.0975.0185.02048
  28. Pal, O.R.; Nayak, S.U.; Gupta, R.B. Preliminary clinical study of kutaja (Holarrhena antidysenterica) linn on medodusti W.S.R. to hyperlipidemia. World J. Pharm. Res., 2019, 8, 1242-1247. doi: 10.20959/wjpr201913-16319
  29. Khan, A.; Khan, S.R.; Gilani, A.H. Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica. Urol. Res., 2012, 40(6), 671-681. doi: 10.1007/s00240-012-0483-1 PMID: 22622371
  30. Aslam, Khan; Bashir, S.; Gilani, A.H. An in vivo study on the diuretic activity of Holarrhena antidysenterica. Afr. J. Pharm. Pharmacol., 2012, 6(7), 454-458. doi: 10.5897/AJPP11.395
  31. Patel, M.; Patel, K.; Gupta, S.N. Effects of Ayurvedic treatment on forty-three patients of ulcerative colitis. Ayu, 2010, 31(4), 478-481. doi: 10.4103/0974-8520.82046 PMID: 22048543
  32. Paranjpe, P.; Patki, P.; Joshi, N. Efficacy of an indigenous formulation in patients with bleeding piles: A preliminary clinical study. Fitoterapia, 2000, 71(1), 41-45. doi: 10.1016/S0367-326X(99)00115-X PMID: 11449468
  33. Dua, V.K.; Verma, G.; Singh, B.; Rajan, A.; Bagai, U.; Agarwal, D.D.; Gupta, N.C.; Kumar, S.; Rastogi, A. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. Malar. J., 2013, 12(1), 194. doi: 10.1186/1475-2875-12-194 PMID: 23758861
  34. Verma, G.; Dua, V.K.; Agarwal, D.D.; Atul, P.K. Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya. Malar. J., 2011, 10(1), 20. doi: 10.1186/1475-2875-10-20 PMID: 21288335
  35. Alshawsh, M.A.; Mothana, R.A.; Al-shamahy, H.A.; Alsllami, S.F.; Lindequist, U. Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants. Evid. Based Complement. Alternat. Med., 2009, 6(4), 453-456. doi: 10.1093/ecam/nem148 PMID: 18955251
  36. Dua, V.K.; Ojha, V.P.; Roy, R.; Joshi, B.C.; Valecha, N.; Devi, C.U.; Bhatnagar, M.C.; Sharma, V.P.; Subbarao, S.K. Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. J. Ethnopharmacol., 2004, 95(2-3), 247-251. doi: 10.1016/j.jep.2004.07.008 PMID: 15507344
  37. Lin, J.; Opoku, A.R.; Geheeb-Keller, M.; Hutchings, A.D.; Terblanche, S.E.; Jäger, A.K.; van Staden, J. Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities. J. Ethnopharmacol., 1999, 68(1-3), 267-274. doi: 10.1016/S0378-8741(99)00130-0 PMID: 10624887
  38. Somanadhan, B.; Varughese, G.; Palpu, P.; Sreedharan, R.; Gudiksen, L.; Wagner Smitt, U.; Nyman, U. An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants. J. Ethnopharmacol., 1999, 65(2), 103-112. doi: 10.1016/S0378-8741(98)00201-3 PMID: 10465650
  39. Ahmad, I.; Beg, A.Z. Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. J. Ethnopharmacol., 2001, 74(2), 113-123. doi: 10.1016/S0378-8741(00)00335-4 PMID: 11167029
  40. Maiti, R.; Das, U.K.; Ghosh, D. Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica. Biol. Pharm. Bull., 2005, 28(7), 1172-1176. doi: 10.1248/bpb.28.1172 PMID: 15997092
  41. Ronge, H.; Blum, L.W. Somatomedin C and other hormones in dairy cow around parturition in newborn calves and milk. J. Appl. Anim. Nutr., 1998, 60, 168-176. doi: 10.1017/S000335610000324X
  42. Shwetha, C.; Latha, K.P.; Asha, K. A study on analgesic activity of Holarrhena antidysenterica leaves. Int. J. Integr. Med., 2014, 2(3), 14-16. doi: 10.5694/j.1326-5377.2000.tb125548.x
  43. Nakalembe, L.; Kasolo, J.N.; Nyatia, E.; Lubega, A.; Bbosa, G.S. Analgesic and anti-inflammatory activity of total crude leaf extract of Phytolacca dodecandra in wistar albino rats. Neurosci. Med., 2019, 10(3), 259-271. doi: 10.4236/nm.2019.103020
  44. Chusri, S.; Na-Phatthalung, P.; Siriyong, T.; Paosen, S.; Voravuthikunchai, S.P. Holarrhena antidysenterica as a resistance modifying agent against Acinetobacter baumannii: Its effects on bacterial outer membrane permeability and efflux pumps. Microbiol. Res., 2014, 169(5-6), 417-424. doi: 10.1016/j.micres.2013.09.004 PMID: 24103863
  45. Sharma, V.; Hussain, S.; Bakshi, M.; Bhat, N.; Saxena, A.K. In vitro cytotoxic activity of leaves extracts of Holarrhena antidysenterica against some human cancer cell lines. Indian J. Biochem. Biophys., 2014, 51(1), 46-51. PMID: 24791416
  46. Hegde, K.; Thakker, S.P.; Joshi, A.B.; Shastry, C.S.; Chandrashekhar, K.S. Anticovusant activity of Carissa carandas linn. root extract in experimental mice. Trop. J. Pharm. Res., 2009, 8(2), 117-125. doi: 10.4314/tjpr.v8i2.44519
  47. Verma, P.; Srivastava, S.; Rao, C.V. Hepatoprotective effect of ethanolic extract of Holarrhena antidysenterica against paracetamol induced toxicity in wistar rats. Res J. Pharm. Tech., 2018, 11(4), 1633-1639. doi: 10.5958/0974-360X.2018.00304.9
  48. Kumar, B.; Vijayakumar, M.; Govindarajan, R.; Pushpangadan, P. Ethnopharmacological approaches to wound healing—Exploring medicinal plants of India. J. Ethnopharmacol., 2007, 114(2), 103-113. doi: 10.1016/j.jep.2007.08.010 PMID: 17884316
  49. Nahar, U.J.; Bhuiyan, M.M.R.; Amsudduzah, A.N.M.; Uddin, M.R.; Maryam, Z. Phytochemical screening, cytotoxic and CNS dependent activities of Holarrhena antidysenterica of leaves and seeds. Int. J. Pharm. Sci. Res., 2015, 6(2), 620-623. doi: 10.13040/IJPSR.0975-8232.6(2).620-23
  50. Kebede, B.; Shibeshi, W. In vitro antibacterial and antifungal activities of extracts and fractions of leaves of Ricinus communis Linn against selected pathogens. Vet. Med. Sci., 2022, 8(4), 1802-1815. doi: 10.1002/vms3.772 PMID: 35182460
  51. Nahar, U.J.; Akter, M.; Bhuiyan, M.M.R.; Rahmatullah, M. Evaluation of analgesic activity of methanolic extract of Holarrhena antidysenterica leaves by tail immersion and hot plate assay methods. World J. Pharm. Res., 2017, 7, 172-178. doi: 10.20959/wjpr20181-10490
  52. Rath, S.; Padhy, R.N. Monitoring iin vitro efficacy of Holarrhena antidysenterica against multidrug resistant enteropathogenic bacteria. Asian Pac. J. Trop. Dis., 2014, 4, S54-S63. doi: 10.1016/S2222-1808(14)60415-1

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