A Review on the Mechanism and Structure-activity Relationship of Resveratrol Heteroaryl Analogues


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Abstract

Resveratrol is one of the most interesting naturally-occurring nonflavonoid phenolic compounds with various biological activities, such as anticancer, neuroprotection, antibacterial, and anti-inflammatory. However, there is no clinical usage of resveratrol due to either its poor activity or poor pharmacokinetic properties. Heteroarenes-modified resveratrol is one pathway to improve its biological activities and bioavailability, and form more modification sites. In this review, we present the progress of heteroaryl analogues of resveratrol with promising biological activities in the latest five years, ranging from the synthesis to the structure-activity relationship and mechanism of actions. Finally, introducing heteroarenes into resveratrol is an effective strategy, which focuses on the selectivity of structure-activity relationship in vivo.

About the authors

Yijun Xiang

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Email: info@benthamscience.net

Yao Xu

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Email: info@benthamscience.net

Jiaxin Li

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Email: info@benthamscience.net

Jingyi Jiang

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Email: info@benthamscience.net

Yanjie Wang

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Email: info@benthamscience.net

Xiaoshun Li

Department of Pharmacy, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Email: info@benthamscience.net

Wenbin Ai

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Email: info@benthamscience.net

Pengbing Mi

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Author for correspondence.
Email: info@benthamscience.net

Zehua Yang

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Author for correspondence.
Email: info@benthamscience.net

Zitong Zheng

Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, The Second Affiliated Hospital, Hengyang Medical School, University of South China

Author for correspondence.
Email: info@benthamscience.net

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