Blood Content of Pro-Inflammatory Chemokines in Patients with First Episode of Schizophrenia before Therapy


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The role of chemokines involved in the processes of neuroinflammation is not well understood in schizophrenia, especially in patients with the first episode of the disease. The aim of the study: to study the content of pro-inflammatory chemokines in the blood of patients with the first episode of paranoid schizophrenia. We examined 18 patients with a diagnosis of F20.09, the control group – 35 people. Determination of the content of 13 chemokines in blood serum was carried out by flow fluorometry. Blood sampling was carried out before the start of therapy. In patients with the first episode of schizophrenia before the appointment of therapy, an increase in the blood level of CCL4 (MIP-1β) by 1.1 times, CXCL9 (MIG) – by 1.4 times, CCL11 (Eotaxin), CXCL5 (ENA-78), CXCL10 (IP-10) – 1.5 times, CXCL1 (GRO-α) – 1.6 times, СCL20 (MIP-3α) – 2.1 times, CXCL8 (IL-8) – 21.0 times. The results obtained indicate the importance of neuroimmune inflammation in the manifestation of schizophrenia with the involvement of chemokines in this process.

About the authors

A. V. Sakharov

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

S. E. Golygina

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

A. S. Prokhorov

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

P. P. Tereshkov

Chita State Medical Academy

Email: nchjournal@gmail.com
Russia, Chita

References

  1. Костюкова А.Б., Мосолов С.Н. // Современная терапия психических расстройств. 2013. № 4. С. 8–17.
  2. Muller N., Ackenheil M. // Progress in Neuropsychopharmacologi and Biological. Psychiatry. 1998. V. 22. P. 1–33.
  3. Monji A., Kato T., Kanba S. // Psychiatry and Clinical Neurosciences. 2009. V. 63. P. 257–265.
  4. Le Thuc O., Blondeau N., Nahon J.L., Rovere C. // Annals of the New York Academy of Sciences. 2015. V. 1351. P. 127–140.
  5. Zlotnik A., Yoshie O. // Immunity. 2000. V. 12. P. 121–127.
  6. Bajetto A., Bonavia R., Barbero S., Schettini G. // Journal of Neurochemistry. 2002. V. 82. № 6. P. 1311–1329.
  7. Dimitrijevic O.B., Stamatovic S.M., Keep R.F., Andjelkovic A.V. // Journal of Cerebral Blood Flow and Metabolism. 2007. V. 26. № 6. P. 797–810.
  8. Jaerve A. // Cell Tissue Res. 2012. № 349. P. 229–248.
  9. Kettenmann H., Kirchhoff F., Verkhratsky A. // Neuron. 2013. V. 77. P. 10–18.
  10. Biber K., Neumann H., Inoue K., Boddeke H. // Trends Neurosci. 2007. V. 30. P. 596–602.
  11. Rostene W., Kitabgi P., Parsadaniantz S.M. // Nat. Rev. Neurosci. 2007 V. 8. P. 895–903.
  12. Van Steenwinckel J., Reaux Le Goazigo A., Pommier B., Mauborgne A., Dansereau M.A., Kitabgi P., Sarret P., Pohl M., Melik-Parsadaniantz S. // J. Neurosci. 2011. V. 31. P. 5865–5875.
  13. Banisadr G., Skrzydelski D., Kitabgi P., Rostene W., Parsadaniantz S.M. // Eur. J. Neurosci. 2003. V. 18. P. 1593–1606.
  14. Dansereau M.A., Gosselin R.D., Pohl M. et al. // J. Neurochem. 2008. V. 106. P. 757–769.
  15. Skrzydelski D., Guyon A., Dauge V., Rovere C., Apartis E., Kitabgi P., Nahon J.L., Rostene W., Parsadaniantz S.M. // J. Neurochem. 2007. V. 102. P. 1175–1183.
  16. Bhattacharyya B.J., Banisadr G., Jung H., Ren D., Cronshaw D.G., Zou Y., Miller R. // J. Neurosci. 2008. V. 28. P. 6720–6730.
  17. Sciaccaluga M., Fioretti B., Catacuzzeno L. // Am. J. Physiol. Cell Physiol. 2010. V. 299. P. 175–184.
  18. Rostene W. // Front. Neuroendocrinol. 2011. V. 32. P. 10–24.
  19. Stuart M.J., Singhal G., Baune B.T. // Front. Cell. Neuroscience. 2015. V. 9. № 10. P. 357–383.
  20. Hong S., Lee E.E., Sirkin M.A. // J. Schres. 2017. № 181. P. 63–69.
  21. Klaus, Federica // Journal of Psychiatric Research. 2021. V. 138. P. 139–145.
  22. Lin Y. // Shanghai Arch. Psychiatry. 2017. V. 29. № 5. P. 287–294.
  23. Guyon A., Skrzydelski D., De Giry I., Rovere C., Conductier G., Trocello J.M., Dauge V., Kitabgi P., Rostene W., Nahon J.L., Melik Parsadaniantz S. // Neuroscience 2009. V. 162. № 4. P. 1072–1080.
  24. Lin Y., Peng Y., Zhu C., Su Y., Shi Y., Lin Z., Chen J., Cui D. // Shanghai Arch. Psychiatry. 2017. V. 29. № 5. P. 287–294.
  25. Сахаров А.В., Мындускин И.В., Терешков П.П., Озорнин А.С., Голыгина С.Е. // Российский психиатрический журнал. 2021. № 4. С. 61–67.
  26. Malmqvist A., Schwieler L., Orhan F., Fatouros-Bergman H., Bauer M., Flyckt L., Cervenka S., Engberg G., Piehl F. // Schizophr. Res. 2019. V. 210. P. 221–227.
  27. Pittaluga A. // Frontiers in Immunology 2017. V. 8. P. 1079.
  28. Bystry R.S., Aluvihare V., Welch K.A., Kallikourdis M., Betz A.G. // Nature Immunology. 2001. V.2 (12). P. 1126–1132.
  29. Harrison S., Thumm L., Nash T.E., Nutman T.B., O’Connell E.M. // Clinical Infectious Diseases. 2021. V. 72(9). P. 326–333.
  30. Warren K.J., Wyatt T.A. // J. Vis. Exp. 2019. V. 151. P. 60060.
  31. Васильева Е.Ф., Брусов О.С. // Психиатрия. 2020. Т. 18. № 3. P. 76–85.
  32. Marro B.S., Grist J.J., Lane T.E. // J. Immunol. 2016. V. 196. P. 1855–1864.
  33. Wu F., Zhao Y., Jiao T. // J. Neuroinflammation. 2015. V. 12. P. 98.
  34. Xu L., Qi X., Zhu C., Wan L. // Neuropsychiatr. Dis. Treat. 2018. V. 14. P. 3393–3403.
  35. Ушаков В.Л., Малашенкова И.К., Костюк Г.П., Захарова Н.В., Крынский С.А., Карташов С.И., Огурцов Д.П., Бравве Л.В., Кайдан М.А., Хайлов Н.А., Чекулаева Е.И., Дидковский Н.А. // Журнал неврологии и психиатрии им. С.С. Корсакова. 2020. Т. 120. № 11. С. 70–78.
  36. Müller M., Carter S., Hofer M.J. // Neuropathol. Appl. Neurobiol. 2010. V. 36. № 5. P. 368–387.
  37. Xia M.Q., Bacskai B.J., Knowles R.B., Qin S.X., Hyman B.T. // J. Neuroimmunol. 2000. V. 108. № 1–2. P. 227–235.
  38. Salmaggi A., Gelati M., Dufour A. // J. Interferon Cytokine Res. 2002. V. 22. № 6. P. 631–640.
  39. Sui Y., Stehno-Bittel L., Li S. // Eur. J. Neurosci. 2006. V. 23. № 4. P. 957–964.
  40. Li H., Gang Z., Yuling H. // J. Immunol. 2006. V. 177. № 6. P. 3644–3656.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2023 А.В. Сахаров, С.Е. Голыгина, А.С. Прохоров, П.П. Терешков