Melancholic Depression is Followed by the Increased Serum Nerve Growth Factor Level

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The aim of the work was to investigate the nerve grown factor (NGF) level in the blood serum in patients with melancholic depression (MD). The investigated group consists of 23 patients. At admission in the clinic (before any antidepressive treatment) the NGF concentration in patient’s serum was 278.28 ± 43.68 pg/mL that was significantly higher in comparison with controls 239.51 ± 22.15 pg/mL, (p < 0.05), respectively. It is supposed, that the increased NGF level in serum of the MD patients can be connected with the impairment of the functioning of the brain-blood barrier and the increase of its permeability for the NGF.

About the authors

M. G. Uzbekov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

S. N. Shikhov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

V. V. Krjukov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

V. V. Brilliantova

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

V. N. Krasnov

Moscow Research Institute of Psychiatry

Email: nchjournal@gmail.com
Russia, Moscow

References

  1. Краснов В.Н. // Журн. неврологии и психиатрии им. С.С. Корсакова. 2012. Т. 112. Вып. 2. Депрессия. С. 3–11.
  2. Levy M., Boulle F., Steinbusch H., Hove D., Kenis G., Lanfumey L. // Psychopharmacology. 2018. V. 235. P. 2195–2220.
  3. Ciafre S., Ferraguti G., Tiressa P., Iannitelli A., Ralli M., Greco A., Chaldakov G., Rosso P., Fico E., Messina M., CaritoV., Tarani L.,Ceccanti M., Fiore M. // Riv, Psichiatr. 2020. V. 55. P. 4–15.
  4. Sofroniew M., Howe C., Mobley W. // Annu. Rev. Neurosci. 2001. V. 24. P. 1217–1281.
  5. Fiore M., Chaldakov G., Aloe L. // Rev. Neurosci. 2009. V. 20. P. 133–45.
  6. Chaldakov G., Fiore M., Stankulov I. // Prog. Brain Res. 2004. V. 146. P. 279–289.
  7. Chao M. // J. Neurosci. Res. 2000. V. 59. P. 353–355.
  8. Hamilton M. // Handbook of Anxiety Disorders / Eds. Last C., Hersen M. Oxford: Pergamon Press, 1988. P. 143–155.
  9. Rao S., Martínez-Cengotitabengoa M., Yao Y., Guo Z., Xu Q., Li S., Zhou X., Zhang F. // J. Psychiatric Research. 2017. V. 86. P. 39–45
  10. Liu X., Zhang T., He S., Hong B., Peng D., Su H., Li F., Tang Y., Lin Z., Fan Y., Jiang K. // Neuropsychiatr. Dis. Treat. 2014. V. 15. № 10. P. 835–840.
  11. Diniz B., Teixeira A., Machado-Vieira R., Talib L., Gattaz W., Forlenza O. // Am. J. Geriatr. Psychiatry. 2013. V. 21. P. 493–496
  12. Wiener C., Ferreira S., Moreira F., Bittencourt G., Oliveira J., Molina M., Jansen K., Souza L., Lara D., Portela L., Silva R., Oses J. // J. of Affective Disorders. 2015. V. 184. P. 245–248. https://doi.org/10.1016/j.jad.2015.05.067
  13. Guo H., Ren Y., Huang B., Wang J., Yang X., Wang Y. Hindawi Genetics Research. 2022. V. 2022. Article ID 1 097 982. 5 p.
  14. Узбеков М.Г., Шихов С.Н., Крюков В.В., Краснов В.Н., Стрелкова И.М., Узбекова Д.Г. // Сибирский вестник психиатрии и наркологии. 2020. Т. 3. С. 5–10.
  15. Patel J., Frey B. // Neural Plasticity. 2015. V. 2015. Article ID 708306. 12 p.
  16. Morris G., Fernandes B., Puri B., Walker A., Carvalho A., Berk M. // Aust. N Z J. Psychiatry. 2018. V. 52. P. 924–948.
  17. Узбеков М.Г. // Социальная и клиническая психиатрия. 2022. Т. 32. С. 83–87.
  18. Максимова Н.М., Булгакова Т.С., Узбеков М.Г. // Социальная и клиническая психиатрия. 2019. Т. 29. С. 71–77.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2023 М.Г. Узбеков, С.Н. Шихов, В.В. Крюков, В.В. Бриллиантова, В.Н. Краснов