Role of VEGF in Angiogenesis and Motor Recovery after Ischemic Stroke

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

Recent scientific studies indicate that angiogenesis and neurogenesis are interrelated processes that determine the functional outcome after ischemic stroke. This literature review presents current data on neurovascular interactions in ischemic stroke, describes the role of the family of vascular endothelial growth factors in the regulation of angiogenesis and neurogenesis, which play a leading role in neuronal survival and neuroplasticity. The authors searched the literature on the pathophysiological role of VEGF in acute cerebral ischemia using the relevant keywords into the PubMed and Google Scholar search engines, as well as Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, eLibrary, and other databases. Clinical studies evaluating the role of VEGF in ischemic stroke are in most cases based on animal models, and their results are ambiguous, which is determined by the versatility of its action. VEGF is an important regulator of angiogenesis, neuroprotection and neurogenesis, but its negative effect has also been proven in the form of an increase in the permeability of the BBB and, as a consequence, cerebral edema, as well as the activation of inflammatory processes. Thus, further study of VEGF is needed to determine its role in functional recovery after ischemic stroke.

About the authors

K. S. Kucherova

Siberian State Medical University

Email: nchjournal@gmail.com
Russia, Tomsk

E. S. Koroleva

Siberian State Medical University

Email: nchjournal@gmail.com
Russia, Tomsk

V. M. Alifirova

Siberian State Medical University

Email: nchjournal@gmail.com
Russia, Tomsk

References

  1. Скворцова В.И., Шетова И.М., Какорина Е.П., Камкин Е.Г., Бойко Е.Л., Алекян Б.Г., Иванова Г.Е., Шамалов Н.А., Дашьян В.Г., Крылов В.В. // Профилактическая медицина. 2018. Т. 21. № 1. С. 4–10.
  2. Khatib R., Arevalo Y.A., Berendsen M.A., Prabhakaran S., Huffman M.D. // Neuroepidemiology. 2018. V. 51. P. 104–112.
  3. GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 // Lancet Neurol. 2019. V. 18. P. 439–458.
  4. Moon S., Chang M.S., Koh S.H., Choi Y.K. // Int. J. Mol. Sci. 2021 V. 22. P. 8543.
  5. Schwab M.E., Strittmatter S.M. // Curr. Opin. Neurobiol. 2014. V. 27. P. 53–60.
  6. Mahar M., Cavalli V. // Nat. Rev. Neurosci. 2018. V. 19. P. 323–337.
  7. Tedeschi A., Bradke F. // Curr. Opin. Neurobiol. 2017. V. 42. P. 118–127.
  8. Jung E., Koh S.H., Yoo M., Choi Y.K. // Int. J. Mol. Sci. 2020. V. 21. P. 2273.
  9. Namiecinska M., Marciniak K., Nowak J.Z. // Postepy Hig. Med. Dosw. 2005. V. 59. P. 573–583.
  10. Gora-Kupilas K., Josko J. // Folia Neuropathol. 2005. V. 43. P. 31–39.
  11. Cao L., Jiao X., Zuzga D.S., Liu Y., Fong D.M., Young D., During M.J. // Nat. Genet. 2004. V. 36. P. 827–835.
  12. Dzietko M., Derugin N., Wendland M.F., Vexler Z.S., Ferriero D.M. // Transl. Stroke Res. 2013. V. 4. P. 189–200.
  13. Nishijima K., Ng Y.-S., Zhong L., Bradley J., Schubert W., Jo N., Akita J., Samuelsson S.J., Robinson G.S., Adamis A.P. // Am. J. Pathol. 2007. V. 171. P. 53–67.
  14. Ma Y., Zechariah A., Qu Y., Hermann D.M. // J. Neurosci. Res. 2012. V. 90. P. 1873–1882.
  15. He Y.Z., Lin B. // J. Clin. Orthopaed. 2012. V. 15. P. 569–573.
  16. Weis S.M., Cheresh D.A. // Nature. 2005. V. 437. P. 497–504.
  17. Zhang H.T., Zhang P., Jiang C.L., Li Y.L. // Chin. J. Diff. Complic. Cases. 2015. V. 14. P. 756–758.
  18. Marti H.J., Bernaudin M., Bellail A., Schoch H., Euler M., Petit E., Risau W. // Am. J. Pathol. 2000. V. 156. P. 965–976.
  19. Stowe A.M., Plautz E.J., Nguyen P., Frost S.B., Eisner-Janowicz I., Barbay S., Dancause N., Sensarma A., Taylor M.D., Zoubina E.V. // J. Cereb. Blood Flow Metab. 2008. V. 28. P. 612–620.
  20. Guan W., Somanath P.R., Kozak A., Goc A., El-Remessy A.B., Ergul A., Johnson M.H., Alhusban A., Soliman S., Fagan S.C. // PLoS ONE. 2011. V. 6. P. 24551.
  21. Krum J.M., Khaibullina A. // Exp. Neurol. 2003. V. 181. P. 241–257.
  22. Zhang Z.G., Zhang L., Tsang W., Soltanian-Zadeh H., Morris D., Zhang R., Goussev A., Powers C., Yeich T., Chopp M. // J. Cereb. Blood Flow Metab. 2002. V. 22. P. 379–392.
  23. Lee M.Y., Ju W.K., Cha J.H., Son B.C., Chun M.H., Kang J.K., Park C.K. // Neurosci. Lett. 1999. V. 265. P. 107–110.
  24. Zan L., Zhang X., Xi Y., Wu H., Song Y., Teng G., Li H., Qi J., Wang J. // Neuroscience. 2014. V. 262. P. 118–128.
  25. Thau-Zuchman O., Shohami E., Alexandrovich A.G., Leker R.R. // J. Cereb. Blood Flow Metab. 2010. V. 30. P. 1008–1016.
  26. Manoonkitiwongsa P.S. // CNS Neurol. Disord. Drug Targets. 2011. V. 10. P. 215–234.
  27. Chen J., Zhang C., Jiang H., Li Y., Zhang L., Robin A., Katakowski M., Lu M., Chopp M. // J. Cereb. Blood Flow Metab. 2005. V. 25. P. 281–290.
  28. Krum J.M., Mani N., Rosenstein J.M. // Neuroscience. 2002. V. 110. P. 589–604.
  29. Lee H.J., Kim K.S., Park I.H., Kim S.U. // PLoS ONE. 2007. V. 2. S. 156.
  30. Ruan G.X., Kazlauskas A. // EMBO J. 2012. V. 31. P. 1692–1703.
  31. Wu W., Duan Y., Ma G., Zhou G., Park-Windhol C., D’Amore P.A., Lei H. // Investig. Ophthalmol. Vis. Sci. 2017. V. 58. P. 6082–6090.
  32. Guix F.X., Uribesalgo I., Coma M., Munoz F.J. // Prog. Neurobiol. 2005. V. 76. P. 126–152.
  33. Geiseler S.J., Morland C. // Int. J. Mol. Sci. 2018. V. 19. P. 1362.
  34. Bauters C., Asahara T., Zheng L.P., Takeshita S., Bunting S., Ferrara N., Symes J.F., Isner J.M. // Circulation. 1995. V. 91. P. 2802–2809.
  35. Ku D.D., Zaleski J.K., Liu S., Brock T.A. // Am. J. Physiol. 1993. V. 265. P. 586–592.
  36. Willmot M., Gray L., Gibson C., Murphy S., Bath P.M. // Nitric Oxide. 2005. V. 12. P. 141–149.
  37. Huang Z., Huang P.L., Ma J., Meng W., Ayata C., Fishman M.C., Moskowitz M.A. // J. Cereb. Blood Flow Metab. 1996. V. 16. P. 981–987.
  38. Salom J.B., Orti M., Centeno J.M., Torregrosa G., Alborch E. // Brain Res. 2000. V. 865. P. 149–156.
  39. Lee S.W., Kim W.J., Choi Y.K., Song H.S., Son M.J., Gelman I.H., Kim Y.J., Kim K.W. // Nat. Med. 2003. V. 9. P. 900–906.
  40. Bella A.J., Lin G., Tantiwongse K., Garcia M., Lin C.S., Brant W., Lue T.F. // Part I. J. Sex. Med. 2006. V. 3. P. 815–820.
  41. You T., Bi Y., Li J., Zhang M., Chen X., Zhang K., Li J. // Sci. Rep. 2017. V. 7. P. 41779.
  42. Greenberg D.A., Jin K. // Nature. 2005. V. 438. P. 954–959.
  43. Rosenstein J.M., Mani N., Khaibullina A., Krum J.M. // J. Neurosci. 2003. V. 23. P. 11036–11044.
  44. Jin K., Mao X.O., Greenberg D.A. // J. Neurobiol. 2006. V. 66. P. 236–242.
  45. Jin K.L., Mao X.O., Greenberg D.A. // Proc. Natl. Acad. Sci. USA. 2000. V. 97. P. 10242–10247.
  46. Svensson B., Peters M., Konig H.G., Poppe M., Levkau B., Rothermundt M., Arolt V., Kogel D., Prehn J.H. // J. Cereb. Blood Flow Metab. 2002. V. 22. P. 1170–1175.
  47. Hayashi T., Abe K., Itoyama Y. // J. Cereb. Blood Flow Metab. 1998. V. 18. P. 887–895.
  48. Bao W.L., Lu S.D., Wang H., Sun F.Y. // Zhongguo Yao Li Xue Bao. 1999. V. 20. P. 313–318
  49. Sorrells S.F., Paredes M.F., Cebrian-Silla A., Sandoval K., Qi D., Kelley K.W., James D., Mayer S., Chang J., Auguste K.I. // Nature. 2018. V. 555. P. 377–381.
  50. Ming G.-L., Song H. // Neuron. 2011. V. 70. P. 687–702.
  51. Ernst A., Frisén J. // PLoS Biol. 2015. V. 13. e1002045.
  52. Gage F.H. // J. Neurosci. 2002. V. 22. P. 612–613.
  53. Jin K., Wang X., Xie L., Mao X.O., Zhu W., Wang Y., Shen J., Mao Y., Banwait S., Greenberg D.A. // Proc. Natl. Acad. Sci. USA. 2006. V. 103. P. 13198–13202.
  54. Wang Y.Q., Cui H.R., Yang S.Z., Sun H.P., Qiu M.H., Feng X.Y., Sun F.Y. // Neurochem. Int. 2009. V. 55. P. 629–636.
  55. Wang Y., Jin K., Mao X.O., Xie L., Banwait S., Marti H.H., Greenberg D.A. // J. Neurosci. Res. 2007. V. 85. P. 740–747.
  56. Kirby E.D., Kuwahara A.A., Messer R.L., Wyss-Coray T. // Proc. Natl. Acad. Sci. USA. 2015. V. 112. P. 4128–4133.
  57. Li W.-L., Fraser J.L., Yu S.P., Zhu J., Jiang Y.-J., Wei L. // Exp. Brain Res. 2011. V. 214. P. 503.
  58. Schanzer A., Wachs F.P., Wilhelm D., Acker T., Cooper-Kuhn C., Beck H., Winkler J., Aigner L., Plate K.H., Kuhn H.G. // Brain Pathol. 2004. V. 14. P. 237–248.
  59. Matsuo R., Ago T., Kamouchi M., Kuroda J., Kuwashiro T., Hata J., Sugimori H., Fukuda K., Gotoh S., Makihara N. // BMC Neurol. 2013. V. 13. P. 32.
  60. Seidkhani-Nahal A., Khosravi A., Mirzaei A. // Neurol. Sci. 2021. P. 1811–1820.
  61. Lee S.C., Lee K.Y., Kim Y.J., Kim S.H., Koh S.H., Lee Y.J. // Eur. J. Neurol. 2010. V. 17(1). P. 45–51.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2.

Download (1MB)
Indexing metadata

Copyright (c) 2023 К.С. Кучерова, Е.С. Королёва, В.М. Алифирова