TOXIC PULMONARY EDEMA BY INHALATION OF PYROLYSIS PRODUCTS OF CHLORINATED PARAFFIN-70 IN RATS

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In the study conducted on laboratory animals (rats) toxic pulmonary edema (TPE) was simulated by inhalation of pyrolysis products of chlorinated paraffin-70 (CP-70). The average-lethal dose of CP-70 burned at 280 ÷ 350 ° C for 3 minutes is 8.1 ± 0.9 g and provides a concentration of hydrogen chloride (HCl) in the chamber at the level of 7325 [5850; 8460] ppm. Under these conditions exposure for 30 minutes led to an increase in the pulmonary rate (LC) in laboratory animals 24 hours after poisoning. The diagnosis of TPE was confirmed histologically by the signs of interstitial and alveolar edema, as well as arterial hypoxemia (TI = 204.5 [180; 228]) indicating respiratory failure. The death of animals was recorded 3 days after application of the pyrolysis products of CP-70. The simulated experimental TPE model can be used to search for the means of pathogenetic therapy of pulmonary toxicants poisoning.

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P. Tolkach

S.M. Kirov Military Medical Academy, RF Ministry of Defense.

编辑信件的主要联系方式.
Email: fake@neicon.ru
194044, Saint-Petersburg. 俄罗斯联邦

V. Basharin

S.M. Kirov Military Medical Academy, RF Ministry of Defense.

Email: fake@neicon.ru
194044, Saint-Petersburg. 俄罗斯联邦

S. Chepur

State Scientific Research Institute of the Military Medicine.

Email: fake@neicon.ru
195043, Saint-Petersburg, Russian Federation. 俄罗斯联邦

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