STRATEGY AND TACTICS OF TNE PESTICIDE MUTAGENECITY ASSESSMENT
- Autores: Rakitskii V.N.1, Revazova Y.A.1, Ilyushina N.A.1
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Afiliações:
- The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)
- Edição: Nº 5 (2015)
- Páginas: 10-12
- Seção: Articles
- ##submission.datePublished##: 01.10.2015
- URL: https://vietnamjournal.ru/0869-7922/article/view/641328
- DOI: https://doi.org/10.15690/vramn508
- ID: 641328
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Resumo
Toxicological and hygienic risk assessment of pesticides widespread use to human health includes the analysis of their mutagenic activity as a compulsory part. A risk assessment strategy of pesticides mutagenic impacts based on their hygiene classification by mutagenicity criterion is presented. Changes in tactical approaches having occurred recently are considered. A set of methods harmonized with international requirements for assessment of mutagenic activity of pesticides, main metabolites and components of their preparative forms is recommended. It allows to determine a hazard class by a given harmful index. Issues are considered in respect to the usage of short-time testing for assessment of generic pesticides mutagenicity, determination of preparative forms potential genotoxicity and forecasting carcinogenic properties of substances under consideration.
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Sobre autores
Valery Rakitskii
The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)
Autor responsável pela correspondência
Email: noemail@neicon.ru
Академик РАН, профессор, и.о. директора ФБУН «Федеральный научный центр гигиены им.Ф.Ф.Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, 141014, Московская область, г. Мытищи, Российская Федерация
e-mail: pesticide@yandex.ru
RússiaYulia Revazova
The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)
Email: noemail@neicon.ru
Доктор биологических наук, профессор, заслуженный деятель науки РФ, ведущий научный сотрудник отдела генетической токсикологии ФБУН Федерального бюджетное учреждение науки «Федеральный научный центр гигиены им.Ф.Ф.Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, 141014, Московская область, г. Мытищи, Российская Федерация
e-mail: Revazova013@gmail.com
RússiaNatalia Ilyushina
The Federal Budgetary Science Institution «F.F. Erisman Federal Scientific Centre of Hygiene», Federal Service for Surveillance on Consumer Rights and Human Well-being (Rospotrebnadzor)
Email: noemail@neicon.ru
Кандидат биологических наук, заведующий отделом генетической токсикологии ФБУН «Федеральный научный центр гигиены им.Ф.Ф.Эрисмана» Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека, 141014, Московская область, г. Мытищи, Российская Федерация
e-mail: Ilyushina-na@mail.ru
RússiaBibliografia
- Rakitskii V.N. ed. Toxicological and hygienic characteristics of pesticides and first aid for poisoning. Вып.1, М. Агрорус, 2011 (in Russian).
- Sanitary Norms and Regulations, SanPiN 1.2.2584-10 “Hygienic requirements for safety of processes of testing, storage, transportation, implementation, use, disposal, and utilization of pesticides and agrochemicals», 2010 (in Russian).
- Potapov A.I., Rakitskii V.N. Pesticide risk assessment for humans. In: International congress on Environmental Health., Hanover, Oct 1-4; 2000, Hanover, Germany, 2000.
- Revazova Yu.A. Genotoxic effects of xenobiotics In.: Kurlyandskiy B.A., Filov V.A., eds. General toxicology, Ch. Moscow: Medicine; 2002: 385-406 (in Russian).
- Rakitskii V.N., Chhvirkiya E.G., Epishina T.M. Comparative biological effects of two technical products of the same active substance - benzotiazinone derivative. In: Scientific papers “Modern Problems of Hygiene and Epidemiology and solutions”, vol. 20, Voronezh: Istoki; 2008: 19-21 (in Russian).
- Chhvirkiya E.G., Epishina T.M. Sanitary and toxicological studies of the active ingredient, sulfonylurea derivative. In: Proceedings of the Congress of V National Forum “Health of the Nation - the basis of Russia’s prosperity”, Section “Sanitary and epidemiological welfare of the population of the Russian Federation”, September 16-19 20Moscow; 2009, vol. 1: 79-80 (in Russian).
- Guideline R 1.2.3156-Evaluation of toxic and hazardous substances and their mixtures for human health. M., Rospotrebnadzor, 2014 (in Russian).
- Zhanataev A.K., Nikitina V.A., Voronina E.S., Durnev A.D. Methodical aspects of DNA damage assessment by comet assay. Prikladnaya toksikologiya, 2011; 2(4): 28-37 (in Russian).
- Rakitskii V.N., Turusov V.S. Mutagenic and carcinogenic activity of chemical compounds. Vestnik RAMN. 2005; 3: 7-9 (in Russian).
- Turusov V.S., Rakitskii V.N., Revazova Yu.A. Once more on the threshold issue in chemical carcinoge nesis. Voprosy onkologii. 1998; 44(4): 468-477 (in Russian).
- Hygienic standards for pesticides in the environment (the list). Hygienic standards GN 1.2.3111-Moscow, 2014 (in Russian).
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