Мақаланы E-mail арқылы жіберу MORPHOLOGIC SPECIFICITIES OF HEPATOPROTECTIVE EFFECTS OF ANTIHYPOXANTS IN EXPERIMENTAL ACUTE LIVER DAMAGE WITH CARBON TETRACHLORIDE
- Авторлар: Repina E.F.1, Khusnutdinova N.Y.1, Timasheva G.V.1, Baigil’din S.S.1, Karimov D.O.1, Musina L.A.2, Myshkin V.A.1, Bakirov A.V.1, Gimadieva A.R.3
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Мекемелер:
- Ufa Institute of Occupational Health and Human Ecology
- All-Russian Centre of Eye and Plastic Surgery
- Ufa Institute of Chemistry of the Russian Academy of Science
- Шығарылым: № 1 (2019)
- Беттер: 43-48
- Бөлім: Articles
- ##submission.datePublished##: 28.02.2019
- URL: https://vietnamjournal.ru/0869-7922/article/view/641159
- DOI: https://doi.org/10.36946/0869-7922-2019-1-43-48
- ID: 641159
Дәйексөз келтіру
Толық мәтін
Аннотация
The article presents the results on liver morphologic changes in acute carbon tetrachloride damage and its preventive correction by antihypoxants: complex oxymethyluracil agents (with sodium succinate and ascorbic acid). It has been shown that carbon tetrachloride causes pronounced morphologic changes in the liver and preventive use of the antihypoxants studied decreases intensity and prevalence of dystrophic processes in liver tissues. The analysis of comparative efficiency of the agents studied has been carried out.
Негізгі сөздер
Авторлар туралы
E. Repina
Ufa Institute of Occupational Health and Human Ecology
Хат алмасуға жауапты Автор.
Email: e.f.repina@bk.ru
Repina Elvira Faridovna
450106, Ufa
N. Khusnutdinova
Ufa Institute of Occupational Health and Human Ecology
Email: fake@neicon.ru
Khusnutdinova Nadezhda Yurevna
450106, Ufa
Ресей
G. Timasheva
Ufa Institute of Occupational Health and Human Ecology
Email: e.f.repina@bk.ru
Timasheva Gulnara Vilevna
450106, Ufa
S. Baigil’din
Ufa Institute of Occupational Health and Human Ecology
Email: baigildin.samat@yandex.ru
Baigildin Samat Sagadatovich
450106, Ufa
D. Karimov
Ufa Institute of Occupational Health and Human Ecology
Email: karimovdo@gmail.com
Karimov Denis Olegovich
450106, Ufa
L. Musina
All-Russian Centre of Eye and Plastic Surgery
Email: morphoplant@mail.ru
Musina Lyalya Akhiyarovna
450075, Ufa
РесейV. Myshkin
Ufa Institute of Occupational Health and Human Ecology
Email: e.f.repina@bk.ru
Myshkin Vladimir Alexandrovich
450106, Ufa
A. Bakirov
Ufa Institute of Occupational Health and Human Ecology
Email: e.f.repina@bk.ru
Bakirov Ahat Barievich
450106, Ufa
A. Gimadieva
Ufa Institute of Chemistry of the Russian Academy of Science
Email: alf_gim@mail.ru
Gimadieva Alfiya Raisovna
450054, Ufa
Әдебиет тізімі
- . Golikov S.N., Sanotsky N.V., Tiunov, L.A. General mechanisms of toxic action. M.: Medicine; 1986; p. 279 (in Russian).
- Okovityi S.N., Smirnov A.V. Antihypoxants. Experimental and clinical pharmacology. 2001, 64, p. 76-80 (in Russian).
- Abdullayev N.Kh., Karimov Kh.Ya. Liver intoxication with hepatotropic poisons. Tashkent, Medicine, 1989, 96 p. (in Russian).
- Bilenko M.V. Ischemic and reperfusion injuries of organs (molecular mechanisms, ways of prevention andtreatment). M., Medicine, 1989, p. 367 (in Russian).
- Lukyanova L.D. Pharmacological correction of mitochondrial dysfunction in hypoxia. Problems of hypoxia: molecular, physiological and medical aspects. M, 2004, p. 456-487 (in Russian).
- Myshkin V.A., Enikeev D.A. Overcoming of hepatotoxicity with antioxidants: reality and perspective. Ufa, Polygraphdesign; 2014; 182 p. (in Russian).
- Myshkin V.A., Bakirov A.B., Repin E.F. Experimental pharmacorrection of toxic liver lesions by antioxidants. Ufa, LLC«Print-2»; 2016; 173 p. (in Russian).
- Myshkin V.A., Enikeev D.A., Srubilin D.A., Gimadieva A.R. Experimental evaluation of pyrimidine derivatives on models of liver toxicity: a review. Medical science, 2016; 03, p. 88-98 (in Russian).
- Myshkin V.A., Bakirov A.B., Repina E.F., Gimadieva A.R. Hepatoprotection using oxymethyluracil. Information methodical letter, Ufa; 2013; 11 p. (in Russian).
- Repina E.F., Gimadieva A.R., Myshkin V.A., Bakirov A.B., Timasheva G.V., Khusnutdinova N.Yu. etc. Antihypoxic activity of a new complex compound of oxymethyluracil with sodium succinate. Toxicological Review, 2017, 2, p. 40-42 (in Russian).
- Repina E.F., Myshkin V.A., Karimov D.O., Timasheva G.V., Khusnutdinova N.Yu. Smolyankin D.A. Antihypoxic activity of complex compound of oxymethyluracil with ascorbic acid. Toxicological Review, 2018, 4, p. 20-23 (in Russian).
- Merkulov G.A. Course of histopathological techniques. M., Medicine, 1969 (in Russian).
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