MORPHOLOGIC SPECIFICITIES OF HEPATOPROTECTIVE EFFECTS OF ANTIHYPOXANTS IN EXPERIMENTAL ACUTE LIVER DAMAGE WITH CARBON TETRACHLORIDE

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Abstract

The article presents the results on liver morphologic changes in acute carbon tetrachloride damage and its preventive correction by antihypoxants: complex oxymethyluracil agents (with sodium succinate and ascorbic acid). It has been shown that carbon tetrachloride causes pronounced morphologic changes in the liver and preventive use of the antihypoxants studied decreases intensity and prevalence of dystrophic processes in liver tissues. The analysis of comparative efficiency of the agents studied has been carried out.

About the authors

E. F. Repina

Ufa Institute of Occupational Health and Human Ecology

Author for correspondence.
Email: e.f.repina@bk.ru

Repina Elvira Faridovna

450106, Ufa


Russian Federation

N. Yu. Khusnutdinova

Ufa Institute of Occupational Health and Human Ecology

Email: fake@neicon.ru

Khusnutdinova Nadezhda Yurevna 

450106, Ufa

 

Russian Federation

G. V. Timasheva

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru

Timasheva Gulnara Vilevna 

450106, Ufa


Russian Federation

S. S. Baigil’din

Ufa Institute of Occupational Health and Human Ecology

Email: baigildin.samat@yandex.ru

Baigildin Samat Sagadatovich

450106, Ufa


Russian Federation

D. O. Karimov

Ufa Institute of Occupational Health and Human Ecology

Email: karimovdo@gmail.com

Karimov Denis Olegovich

450106, Ufa


Russian Federation

L. A. Musina

All-Russian Centre of Eye and Plastic Surgery

Email: morphoplant@mail.ru

Musina Lyalya Akhiyarovna

450075, Ufa

Russian Federation

V. A. Myshkin

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru

Myshkin Vladimir Alexandrovich

450106, Ufa


Russian Federation

A. V. Bakirov

Ufa Institute of Occupational Health and Human Ecology

Email: e.f.repina@bk.ru

Bakirov Ahat Barievich

450106, Ufa


Russian Federation

A. R. Gimadieva

Ufa Institute of Chemistry of the Russian Academy of Science

Email: alf_gim@mail.ru

Gimadieva Alfiya Raisovna

450054, Ufa


Russian Federation

References

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  2. Okovityi S.N., Smirnov A.V. Antihypoxants. Experimental and clinical pharmacology. 2001, 64, p. 76-80 (in Russian).
  3. Abdullayev N.Kh., Karimov Kh.Ya. Liver intoxication with hepatotropic poisons. Tashkent, Medicine, 1989, 96 p. (in Russian).
  4. Bilenko M.V. Ischemic and reperfusion injuries of organs (molecular mechanisms, ways of prevention andtreatment). M., Medicine, 1989, p. 367 (in Russian).
  5. Lukyanova L.D. Pharmacological correction of mitochondrial dysfunction in hypoxia. Problems of hypoxia: molecular, physiological and medical aspects. M, 2004, p. 456-487 (in Russian).
  6. Myshkin V.A., Enikeev D.A. Overcoming of hepatotoxicity with antioxidants: reality and perspective. Ufa, Polygraphdesign; 2014; 182 p. (in Russian).
  7. Myshkin V.A., Bakirov A.B., Repin E.F. Experimental pharmacorrection of toxic liver lesions by antioxidants. Ufa, LLC«Print-2»; 2016; 173 p. (in Russian).
  8. Myshkin V.A., Enikeev D.A., Srubilin D.A., Gimadieva A.R. Experimental evaluation of pyrimidine derivatives on models of liver toxicity: a review. Medical science, 2016; 03, p. 88-98 (in Russian).
  9. Myshkin V.A., Bakirov A.B., Repina E.F., Gimadieva A.R. Hepatoprotection using oxymethyluracil. Information methodical letter, Ufa; 2013; 11 p. (in Russian).
  10. Repina E.F., Gimadieva A.R., Myshkin V.A., Bakirov A.B., Timasheva G.V., Khusnutdinova N.Yu. etc. Antihypoxic activity of a new complex compound of oxymethyluracil with sodium succinate. Toxicological Review, 2017, 2, p. 40-42 (in Russian).
  11. Repina E.F., Myshkin V.A., Karimov D.O., Timasheva G.V., Khusnutdinova N.Yu. Smolyankin D.A. Antihypoxic activity of complex compound of oxymethyluracil with ascorbic acid. Toxicological Review, 2018, 4, p. 20-23 (in Russian).
  12. Merkulov G.A. Course of histopathological techniques. M., Medicine, 1969 (in Russian).

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Copyright (c) 2019 Repina E.F., Khusnutdinova N.Y., Timasheva G.V., Baigil’din S.S., Karimov D.O., Musina L.A., Myshkin V.A., Bakirov A.V., Gimadieva A.R.


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