EXPERIMENTAL STUDIES OF BIOCHEMICAL SYSTEMS OF WHITE RATS WITH FENTANYL ACUTE INTOXICATION

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Abstract

Experimental studies of the biochemical systems of white outbred rats in a single intoxication with fentanyl have been carried out. It has been established that acute intravenous intoxication with synthetic narcotic analgesics (fentanyl) leads to an intensification of lipid peroxidation processes indicating the development of oxidative stress. The peculiar biochemical changes of acute drug intoxication are revealed. They are represented by certain combinations of impaired biochemical parameters of blood serum.

About the authors

D. V. Gorbunov

Institute of Toxicology of the Federal Medical and Biological Agency.

Author for correspondence.
Email: fake@neicon.ru
192019, Saint-Petersburg. Russian Federation

L. P. Erdniev

The 33rd Central Scientific Research Institute, Ministry of Defense of the Russian Federation.

Email: fake@neicon.ru
412918, Volsk-18. Russian Federation

I. A. Nelga

The 33rd Central Scientific Research Institute, Ministry of Defense of the Russian Federation.

Email: fake@neicon.ru
412918, Volsk-18. Russian Federation

I. V. Medvetsky

The 33rd Central Scientific Research Institute, Ministry of Defense of the Russian Federation.

Email: fake@neicon.ru
412918, Volsk-18. Russian Federation

A. Yu. Mikshta

The 33rd Central Scientific Research Institute, Ministry of Defense of the Russian Federation.

Email: fake@neicon.ru
412918, Volsk-18. Russian Federation

E. Yu. Andreeva

The 33rd Central Scientific Research Institute, Ministry of Defense of the Russian Federation.

Email: fake@neicon.ru
412918, Volsk-18. Russian Federation

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Copyright (c) 2018 Gorbunov D.V., Erdniev L.P., Nelga I.A., Medvetsky I.V., Mikshta A.Y., Andreeva E.Y.


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