№ 3 (2018)

N.V. Sklifosovsky Research Institute for Emergency Medicine, Healthcare Department of Moscow|, 129090, Moscow, Russian Federation Research and Applied Toxicology Center of Federal Medical and Biological Agency|, 129090, Moscow, Russian Federation Russian Medical Academy of Continuous Professional Education, RF Ministry of Health|, 125993, Moscow, Russian Federation The problem of correction of disturbed homeostasis parameters in critical conditions, including acute poisoning, has revealed its increasing importance in recent years. In this respect, extracorporeal methods of detoxification (hemosorption, hemodialysis, etc.) and physio- and chemohemotherapy are quite effective. With the help of these methods positive changes in hemorheological, immune and other parameters are achieved, that increase significantly the overall results of treatment of patients. At the same time, targeted correction of disturbed homeostasis outside detoxification activities is still carried out mainly through infusion therapy. Along with this in recent years a growing number of scientific papers devoted to the correction of homeostatic disorders by enteral administration of special solutions in emergency conditions has appeared. However, this approach, although physiological and technically simple, has not yet been studied in clinical toxicology, and this fact encourages further research in this direction.

The aim of the study was to assess the role of the cellular component of the stroma in liver regeneration after its toxic damage. The experimental model of toxic hepatitis caused by intraperitoneal administration of tetrachloromethane (CCl4) showed that regeneration processes in the liver on the 3rd day are manifested in an increase in binuclear hepatocytes, Ki-67 + cells and hepatocytes dividing by mitosis. The reaction of the stromal component is expressed in an increase in the number of CD45 +, mast and sinusoidal cells (SC). On the 7th day of the development of toxic hepatitis the hepatocyte alteration increases, that is accompanied by a sharp decrease in the mitotic index and the number of Ki-67 + cells. In the stromal component there is a decrease in the number of sinusoidal cells, CD45 + and a significant increase in mast cells with a high secretion granule content.

The article provides a review of the literature on the chemical leasing program implemented by UNIDO, the UN Department for industrial development. The advantages and perspectives of this business model in comparison with the classic version are analyzed on specific examples. It is shown that this model is implemented in the framework of the concept of sustainable development.