ASSESSMENT OF THE TOXICITY AND HAZARD OF SODIUM LAURYL SULFATE AT DIFFERENT EXPOSURE ROUTES

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Abstract

Sodium lauryl sulfate is the most common surfactant used in the production of detergents, chloroprene rubber, plastics, artificial furs and in pharmaceutical industry. Sodium lauryl sulfate is a moderately hazardous substance when introduced into the stomach (DL50 for white mice and rats is in the range of 2086-2700 mg/kg), has a pronounced local irritant effect on the skin and mucous membranes of the eyes, has a skin-resorptive, sensitizing and pronounced cumulative effects. The threshold for acute inhalation action is set at 15,3 mg/m3 for changes in the function of the nervous system and irritating effects on the mucous membranes of the upper respiratory tract (an increase in the total number of cells in the nasal flushes).

Recommended for approval tentative safe exposure level of sodium lauryl sulfate in the air of the working area is 0.2+ mg/m3 (aerosol).

About the authors

M. V. Bidevkina

Scientifi c Research Institute of Disinfectology of Rospotrebnadzor

Author for correspondence.
Email: bidevkinamv@niid.ru

Bidevkina Marina Vasil’evna

117246, Moscow

Russian Federation

M. I. Golubeva

Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»

Email: golubevamargo@mail.ru

Golubeva Margarita Ivanovna

142450, Staraya Kupavna

Russian Federation

A. V. Limantsev

Scientifi c Research Institute of Disinfectology of Rospotrebnadzor

Email: av.lim@yandex.ru

Limantsev Anatoliy Vladimirovich

117246, Moscow

Russian Federation

I. N. Razumnaya

Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»

Email: irina.r.3@mail.ru

Razumnaya Irina Nikolaevna

142450, Staraya Kupavna

Russian Federation

T. N. Potapova

Scientifi c Research Institute of Disinfectology of Rospotrebnadzor

Email: potapovatn@niid.ru

Potapova Tat’yana Nikolaevna

117246, Moscow

Russian Federation

E. A. Fedorova

Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»

Email: emfed@mail.ru

Fedorova Emma Alexeevna

142450, Staraya Kupavna

Russian Federation

References

  1. OECD; SIDS Initial Assessment Report for SIAM 5. Sodium dodecyl sulphate (CAS No: 151-21-3). – 2005 – p. 17-20. Available at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1315 (accsessed 07 June, 2019)

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Copyright (c) 2020 Bidevkina M.V., Golubeva M.I., Limantsev A.V., Razumnaya I.N., Potapova T.N., Fedorova E.A.


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