Pectins in prevention of acute poisoning

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The purpose of the review is to analyze the possibilities of using of pectin enterosorbents for the prevention of acute poisoning. Low-esterified pectins exhibit high sorbing activity against multicharged cations, are highly adhesive to the mucous membranes of the digestive tract and are able to reduce non-specifically the permeability of the enterohematic barrier. The expected duration of the preventive effect of pectin enterosorbents is 4-5 hours after their administration. In combination with good tolerability and ease of use, this indicates the prospects of low-esterified pectins as means of drug prevention of acute poisoning in case of increased risk of oral or inhalation intake of heavy metals, nuclear fission materials and nuclear fission products.

Sobre autores

Yu. Ivnitsky

Institute of Toxicology of the Federal Medical Biological Agency

Autor responsável pela correspondência
Email: neugierig@mail.ru

Ivnitsky Yury Yurievich

192019, Saint Petersburg

Rússia

K. Krasnov

Institute of Toxicology of the Federal Medical Biological Agency

Email: krasnov_tox@mail.ru

Krasnov Konstantin Andrejevich

192019, Saint Petersburg

Rússia

V. Rejniuk

Institute of Toxicology of the Federal Medical Biological Agency

Email: vladton@mail.ru

Rejniuk Vladimir Leonidovich

192019, Saint Petersburg

Rússia

N. Lapina

Institute of Toxicology of the Federal Medical Biological Agency

Email: lapina2005@inbox.ru

Lapina Natalja Vadimovna

192019, Saint Petersburg

Rússia

M. Melikhova

Institute of Toxicology of the Federal Medical Biological Agency

Email: melihovamarina@inbox.ru

Melikhova Marina Valentinovna

192019, Saint Petersburg

Rússia

A. Golovko

Institute of Toxicology of the Federal Medical Biological Agency

Email: prgolovko@inbox.ru

Golovko Alexandr Ivanovich

192019, Saint Petersburg

Rússia

A. Krasnova

Institute of Toxicology of the Federal Medical Biological Agency

Email: apreski@mail.ru

Krasnova Alexandra Andrejevna

192019, Saint Petersburg

Rússia

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Declaração de direitos autorais © Ivnitsky Y.Y., Krasnov K.A., Rejniuk V.L., Lapina N.V., Melikhova M.V., Golovko A.I., Krasnova A.A., 2020



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