Pectins in prevention of acute poisoning

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Abstract

The purpose of the review is to analyze the possibilities of using of pectin enterosorbents for the prevention of acute poisoning. Low-esterified pectins exhibit high sorbing activity against multicharged cations, are highly adhesive to the mucous membranes of the digestive tract and are able to reduce non-specifically the permeability of the enterohematic barrier. The expected duration of the preventive effect of pectin enterosorbents is 4-5 hours after their administration. In combination with good tolerability and ease of use, this indicates the prospects of low-esterified pectins as means of drug prevention of acute poisoning in case of increased risk of oral or inhalation intake of heavy metals, nuclear fission materials and nuclear fission products.

About the authors

Yu. Yu. Ivnitsky

Institute of Toxicology of the Federal Medical Biological Agency

Author for correspondence.
Email: neugierig@mail.ru

Ivnitsky Yury Yurievich

192019, Saint Petersburg

Russian Federation

K. A. Krasnov

Institute of Toxicology of the Federal Medical Biological Agency

Email: krasnov_tox@mail.ru

Krasnov Konstantin Andrejevich

192019, Saint Petersburg

Russian Federation

V. L. Rejniuk

Institute of Toxicology of the Federal Medical Biological Agency

Email: vladton@mail.ru

Rejniuk Vladimir Leonidovich

192019, Saint Petersburg

Russian Federation

N. V. Lapina

Institute of Toxicology of the Federal Medical Biological Agency

Email: lapina2005@inbox.ru

Lapina Natalja Vadimovna

192019, Saint Petersburg

Russian Federation

M. V. Melikhova

Institute of Toxicology of the Federal Medical Biological Agency

Email: melihovamarina@inbox.ru

Melikhova Marina Valentinovna

192019, Saint Petersburg

Russian Federation

A. I. Golovko

Institute of Toxicology of the Federal Medical Biological Agency

Email: prgolovko@inbox.ru

Golovko Alexandr Ivanovich

192019, Saint Petersburg

Russian Federation

A. A. Krasnova

Institute of Toxicology of the Federal Medical Biological Agency

Email: apreski@mail.ru

Krasnova Alexandra Andrejevna

192019, Saint Petersburg

Russian Federation

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Copyright (c) 2020 Ivnitsky Y.Y., Krasnov K.A., Rejniuk V.L., Lapina N.V., Melikhova M.V., Golovko A.I., Krasnova A.A.


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