Pectins in prevention of acute poisoning

Capa

Citar

Texto integral

Resumo

The purpose of the review is to analyze the possibilities of using of pectin enterosorbents for the prevention of acute poisoning. Low-esterified pectins exhibit high sorbing activity against multicharged cations, are highly adhesive to the mucous membranes of the digestive tract and are able to reduce non-specifically the permeability of the enterohematic barrier. The expected duration of the preventive effect of pectin enterosorbents is 4-5 hours after their administration. In combination with good tolerability and ease of use, this indicates the prospects of low-esterified pectins as means of drug prevention of acute poisoning in case of increased risk of oral or inhalation intake of heavy metals, nuclear fission materials and nuclear fission products.

Sobre autores

Yu. Ivnitsky

Institute of Toxicology of the Federal Medical Biological Agency

Autor responsável pela correspondência
Email: neugierig@mail.ru

Ivnitsky Yury Yurievich

192019, Saint Petersburg

Rússia

K. Krasnov

Institute of Toxicology of the Federal Medical Biological Agency

Email: krasnov_tox@mail.ru

Krasnov Konstantin Andrejevich

192019, Saint Petersburg

Rússia

V. Rejniuk

Institute of Toxicology of the Federal Medical Biological Agency

Email: vladton@mail.ru

Rejniuk Vladimir Leonidovich

192019, Saint Petersburg

Rússia

N. Lapina

Institute of Toxicology of the Federal Medical Biological Agency

Email: lapina2005@inbox.ru

Lapina Natalja Vadimovna

192019, Saint Petersburg

Rússia

M. Melikhova

Institute of Toxicology of the Federal Medical Biological Agency

Email: melihovamarina@inbox.ru

Melikhova Marina Valentinovna

192019, Saint Petersburg

Rússia

A. Golovko

Institute of Toxicology of the Federal Medical Biological Agency

Email: prgolovko@inbox.ru

Golovko Alexandr Ivanovich

192019, Saint Petersburg

Rússia

A. Krasnova

Institute of Toxicology of the Federal Medical Biological Agency

Email: apreski@mail.ru

Krasnova Alexandra Andrejevna

192019, Saint Petersburg

Rússia

Bibliografia

  1. Sofronov G.A, Aleksandrov M.V., Golovko A.I. et al. Extreme toxicology. SPb: Medkniga «ELBI-SPb»; 2016 (in Russian).
  2. Mittermeier R.A., Rylands A.B., Wilson D.E. (eds.). Handbook of the mammals of the world: Vol. 3, Primates. Oxford: Lynx Edicions; 2013.
  3. Kravkov N.P. Fundamentals of Pharmacology. 1st ed., part 2. SPb.: Edition N.L. Rikkera,1904 (in Russian).
  4. Panfilova V.N., Taranushenko T.E. The use of enterosorbents in clinical practice. Pediatric pharmacology. 2012; 9 (6): 34 9 (in Russian).
  5. Briskin B.S., Vyortkin A.L., Aleksayan L.A. Rational Pharmacotherapy for Emergencies: A Guide for Practitioners. M.: Literatura, 2007 (in Russian).
  6. Lopetuso L.R., Scaldaferri F., Bruno G., Petito V., Franceschi F., Gasbarrini A. The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors. Eur. Rew. Med. Pharm. Sci. 2015; 19: 1068 76.
  7. Directory of drugs Vidal. Description of medicines. Available at: https://med-09.ru/at0.htm (in Russian).
  8. State Register of Medicines, 2020. Electronic resource. Available at: http://grls.rosminzdrav.ru/Default.aspx (in Russian).
  9. Kormishina A.E., Mizina P.G., Solov'yova I.L. The pharmaceutical market of drugs with adsorption action: conditions and prospects. Medical Bulletin of Bashkortostan. 2018; 13 (6): 55 61 (in Russian).
  10. Asp N.G. Dietary fibre analysis – an overview. Eur. J. Clin. Nutr. 1995; 49 (3): S42 7.
  11. Ciudad-Mulero M., Fernándes-Ruiz V., Matallana-Gonzáles M., Morales P. Dietary fiber sourses and human benefits: the case study of cereal and pseudocereals. Adv. Food Nutr. Res. 2019; 90: 83 134.
  12. Vasilenko Yu.K. Synthesis and study of the physicochemical and hepatoprotective properties of pectin substances. Chemical Pharmaceutical Journal. 1997; 31 (6): 28 9 (in Russian).
  13. Komissarenko S.N., Spiridonov V.N. Pectins their properties and applications. Plant Resources. 1998; 34 (1): 111 19 (in Russian).
  14. Hotimchenko Yu.M. Polisorbovit. Tomsk: NTL, 2001 (in Russian).
  15. Katceva G.P. Investigation of the interaction of pectin substances with salts of copper, mercury, zinc and cadmium. Chemistry of natural compounds. 1988; (2): 171 75 (in Russian).
  16. Trahtenberg I., Krasnyuk E., Lubyanova I., Demchenko V., Kozlov K., Lampeka E., Harchenko T. Pectins in the individual prophylaxis of chronic lead intoxication. Toxicological Review. 1998; (4): 32 5 (in Russian).
  17. Eliaz I., Weil E., Schwarzbach, Wilk B Modified citrus pectin/alginate dietary supplement increased fecal excretion of and healthy eldery. Nutrients. 2019; 11 (7): 1554. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683049/
  18. Nesterenko V.B., Nesterenko A.V. Decorporation of Chernobyl radionuclides. Ann. N.Y. Acad. Sci. 2009; 1181: 30310.
  19. Kutcenko S.A. Fundamentals of toxicology. SPb.: FOLIANT. 2004 (in Russian).
  20. O’Grady J., Murphy C.L., Burry L., Shanahan F., Buckly M. Defining gastrointestinal transit time using video capsule endoscopy: a study of healthy subjects. Endosc. Int. Open. 2020; 8 (3): E396 E400.
  21. Sabando C., Ide W., Rodrigez-Diez M., Cabrera-Barjas G., Gastano J., Bousa R., et al. A novel hydrocolloid film based on pectin, starch and gunerra tinctoria and Ungi molinae plant extracts for wound dressing applications. Curr. Top. Med. Chem. 2020; 20 (4): 280 92.
  22. Jorgensen L., Klösgen B., Simonsen A.C., Borch J., Hagesaether E. New insights into the mucoadhesion of pectins by AFM roughness parameters in combination with SPR. Int. J. Pharm. 2011; 411 (1-2): 162 8.
  23. Ishisono K., Mano T., Yabe T., Kitaguchi K. Dietary fiber pectin ameliorates experimental colitis in a neutral sugar side chain-dependent manner. Front. Immunol. 2019; 10: 2979. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930924/
  24. Sahasrabudhe N.M., Beukema M., Tian L., Troost B., Scholte J., Bruininx E., Bruggeman G., et al. Dietary fi pectin directly blocks toll-like receptor 2-1 and prevents doxorubicin-induced ileitis. Front. Immunol. 2018; 9: 383. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839092/
  25. Çagan E., Ceilan S., Mengi S., Çagan H. Evaluation of gelatin tannate aganist symptoms of acute diarrhea pediatric patients. Med. Sci. Monit. 2017; 23: 2029 34.
  26. Wilms E., Jonkers D., Savelkoul H., Elizalde M., Tischmann L., de Vos P., Masclee A., Troost F. The impact of pectin supplementation on intestinal barrier function in healthy young and healthy eldery. Nutrients. 2019; 11 (7): 1554. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683049/.
  27. Vogt L.M., Meyer D., Pullens G., Faas M., Venema K., Ramasamy U., et al. Toll-like receptor 2 activation by beta 2 –>1-fructans protects barrier function of T84 human intestinal epithelial cells in a chain length-dependent manner. J. Nutr. 2014; 144 (7): 1002 8.
  28. Corrêa-Oliveira R., Fachi J.L., Vieira A., Sato F.T., Vinolo M.A.R. Regulation of immune cell function by short-chain fatty acids. Clin. Transl. Immunol. 2016; 5 (4): e73. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855267/

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar

Declaração de direitos autorais © Ivnitsky Y.Y., Krasnov K.A., Rejniuk V.L., Lapina N.V., Melikhova M.V., Golovko A.I., Krasnova A.A., 2020


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 81728 от 11 декабря 2013.