THE EFFECT OF SUBACUTE INTOXICATION WITH ETHYLENE CHLOROHYDRIN ON IMMUNE RESPONSES, TH1 AND TH2 LYMPHOCYTE FUNCTION AND CYTOKINE LEVELS IN RATS BLOOD

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In experiments on outbred albino rats, it was established that subacute intoxication with ethylene chlorohydrin (0.2 LD50 daily for 4 days) causes a decrease in Th1 and Th2 lymphocytes function to the same extent, diminishes parameters of humoral and cellular immune responses and the content of immunoregulatory cytokines IFN- , IL-2, IL-4 in blood, increases concentrations of pro-inflammatory cytokine IL-6 and anti-inflammatory cytokine IL-10.

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P. Zabrodskii

Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”

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Email: noemail@neicon.ru
俄罗斯联邦

V. Maslyakov

Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”

Email: noemail@neicon.ru
俄罗斯联邦

M. Gromov

Branch of the Private Educational Institution of Higher Education “ Saratov Medical University “REVIZ”

Email: noemail@neicon.ru
俄罗斯联邦

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