Сиртуины и их роль в регуляции метаболизма мультипотентных мезенхимальных стромальных клеток

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Сиртуины – белки семейства гистоновых деацетилаз, вовлеченные в эпигенетическую регуляцию различных клеточных функций. В данном обзоре на основании имеющихся литературных данных проведен анализ функций сиртуинов в мультипотентных мезенхимальных стромальных клетках (ММСК). Данные белки играют весьма важную роль в энергетическом обмене, дифференцировке, старении ММСК. Показана их роль в защите от окислительного стресса. Описано участие сиртуинов в специфичной для ММСК регуляции генов.

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М. В. Лобанова

Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации Институт медико-биологических проблем РАН

Автор, ответственный за переписку.
Email: pogodina_m@mail.ru
Россия, 123007, Москва

Л. Б. Буравкова

Федеральное государственное бюджетное учреждение науки Государственный научный центр Российской Федерации Институт медико-биологических проблем РАН

Email: buravkova@imbp.ru
Россия, 123007, Москва

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