Convenient Preparation of tert-Butyl Amino Acid Esters from tert-Butanol

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Abstract

A preparation of tert-butyl esters of amino acid is described that proceeds from protected amino acids and tert-butanol using anhydrous magnesium sulfate and an excess of boron trifluoride diethyl etherate as additional reagents. The method affords tert-butyl esters in good yields and a variety of amino acid side chains and substituents tolerate the reaction conditions.

About the authors

V. N. Azev

Branch of Shemyakin and Ovchinnikov Bioorganic Chemistry Institute RAS,

Author for correspondence.
Email: viatcheslav.azev@bibch.ru
Russia, 142290, Puschino, prosp. Nauki 6

A. N. Chulin

Branch of Shemyakin and Ovchinnikov Bioorganic Chemistry Institute RAS,

Email: viatcheslav.azev@bibch.ru
Russia, 142290, Puschino, prosp. Nauki 6

M. V. Molchanov

Istitute for Theoretical and Experimental Biophysics RAS

Email: viatcheslav.azev@bibch.ru
Russia, 142290, Puschino, Institutskaya ul. 3

A. I. Miroshnikov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: viatcheslav.azev@bibch.ru
Russia, 117997, Moscow, ul. Miklukho-Maklaya 16/10

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Copyright (c) 2023 В.Н. Азев, А.Н. Чулин, М.В. Молчанов, А.И. Мирошников