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卷 95, 编号 3-4 (2025)
Articles
Synthesis and Biological Evaluation of N-Aminoalkil Derivatives of Sulfanilamide Reaction
摘要
A series of 19 derivatives of sulfanilamide was synthesized by the reaction of chloroacetamide, trichloroacetamide and chloropropionamide with N-nucleophiles. It was shown that N-trichloroacetylsulfanilamide in reactions with amines forms products of substitution of the trichloromethyl group, while N-chloroacetylsulfanilamide and N-chloropropionylsulfanilamide react with substitution of the halogen atom. An assessment of the antibacterial properties of the synthesized structures was carried out, showing the absence of activity with respect to E. coli and St. aureus strains. Two aminoalkyl-containing sulfonamides – 2-(4-benzylpiperidin-1-yl)-N-(4-sulfamoylphenyl)acetamide and 2-(4-nitropyrazol-1-yl)-N-(4-sulfamoylphenyl)acetamide – showed inhibitory properties against the human monoamine oxidase enzyme, comparable in IC50 value to the drug zonisamide.
80-91
Synthesis, Structure and Analgesic Activity of N-Alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides
摘要
A series of new N-alkyl-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides were obtained by decyclization of 4-arylamino-2-tert-butyl-2,5-dihydro-5-oxofuran-2-yl acetates under the action of aliphatic amines. The analgesic activity of the synthesized compounds was studied.
92-98
Synthesis and Antioxidant Activity of 4-[(4-Aroyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-en-3-yl)amino]benzoic Acids
摘要
4-[(4-Аroyl-2,6,8,10-tetraoxo-1-oxa-7,9-diazaspiro[4.5]dec-3-en-3-yl)amino]benzoic acids were synthesized by reacting 4-{[(2Z)-4-aryl-1-methoxy-1,4-dioxobut-2-en-2-yl]amino}benzoic acids with alloxan in glacial acetic acid. The structure of the obtained compounds was confirmed by IR, 1H and 13C{1H} NMR spectroscopy. The antioxidant activity of the synthesized compounds was studied.
99-106
Synthesis of 6,9-Diaryl-5Н-imidazo[2,1-d][1,2,5]triazepines and Their Dihydro Derivatives
摘要
2-(2-Benzoyl-1H-imidazol-1-yl)-1-arylethanones were obtained by alkylation of 2-benzoylimidazole with phenacyl bromides; their cyclization with hydrazine hydrate leads to the formation of previously undescribed 6-aryl-9-phenyl-5H-imidazo[2,1-d][1,2,5]triazepines. The reduction of the latter with sodium borohydride in a dioxane medium leads to the production of 6-aryl-9-phenyl-6,7-dihydro-5H-imidazo[2,1-d][1,2,5]triazepines.
107-113
Synthesis, Structure and Antioxidant Activity of 4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-а]pyrimidine-2(1H)-ones
摘要
4-Aryl-3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2(1H)-ones were obtained by the reaction of dimethyl malonate (diethyl malonate), aromatic aldehyde, and 1H-benzimidazole-2-amine in methanol (ethanol) in the presence of piperidine for 6 h. Structure of the compounds was confirmed by 1H, 13C NMR spectroscopy and X-ray diffraction analysis. Antioxidant activity of the synthesized compounds was studied.
114-120
Europium Complexes with Fluorinated Carbazole-Containing Tetraketones
摘要
Complex compounds of fluorine-containing tetraketones on the basis of carbazole with europium(III) ions were synthesized, the luminescence-spectral properties of the obtained complexes were evaluated and the exact stoichiometric composition was established. The position of the maximum in the excitation spectrum (≥ 370 nm) of the complexes, a significant Stokes shift (> 250 nm), and a long lifetime of the excited state (400–700 μs) allow us to consider the synthesized complexes as potential reagents for time-resolved fluorescence immunoassay.
121-130
Extraction of REE(III) with Mixtures of Picrolonic Acid and Bis-Carbamoylmethylphosphine Oxides
摘要
It was found that the extraction of REE(III) from weakly acidic chloride solutions into an organic phase containing bis-carbamoylmethylphosphine oxides increases significantly in the presence of picrolonic acid. The stoichiometry of the extracted complexes was determined, the effect of the aqueous phase composition, the nature of the organic solvent and the structure of bis-CMPO on the efficiency of metal ion extraction into the organic phase was considered. The use of picrolonic acid as a chelating component of the extraction mixture leads to a significantly greater increase in the extraction of REE(III) compared to 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone.
131-139
Effect of Synthesis Conditions on the Composition of Palladium Sulfides
摘要
The formation process of Pd-S-containing nanoparticles from Pd(acac)2 and orthorhombic sulfur in hydrogen under mild conditions at different Pd:S ratios was studied using a combination of UV spectroscopy, high-resolution transmission electron microscopy, electron diffraction and X-ray powder diffraction methods, nanoparticles’ average size, phase and elemental composition, morphology and microstructure were determined. The transition of solid solutions of sulfur in palladium or in palladium sulfide into palladium sulfides enriched in sulfur after high-temperature treatment of Pd–S-containing samples was established. The possibility of obtaining phase-pure palladium sulfides Pd4S, PdS without loss of sulfur in the sulfur-containing precursor is shown.
140-152