Synthesis of 1-aminoalkyl-5,6-diaryl-2-oxopyrrolo[3,4-c]pyrazoles

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Abstract

The reaction of substituted 1-aminoalkyl-3-hydroxy-3-pyrrolin-2-ones with hydrazine hydrate in boiling glacial acetic acid leads to the formation of 1-aminoalkyl-5,6-diaryl-2-oxopyrrolo[3,4-c]pyrazoles. The structure of the obtained compounds was confirmed by IR, 13C NMR and 1H NMR spectroscopy methods.

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About the authors

N. N. Kasimova

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: pufmail135@gmail.com
ORCID iD: 0009-0001-6348-7333
Russian Federation, Perm

V. L. Gein

Perm State Pharmaceutical Academy of the Ministry of Health of the Russian Federation

Email: pufmail135@gmail.com
ORCID iD: 0000-0002-8512-0399
Russian Federation, Perm

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2. Scheme 1. R1 = CH(CH3)NH2∙HCl, R2 = 4-Br, R3 = 4-Cl (а); R1 = CH(CH3)NH2∙HCl, R2 = 4-Br, R3 = 4-F (б); R1 = CH(CH3)NH2∙HCl, R2 = 4-Cl, R3 = 4-F (в); R1 = (CH2)2N(CH3)2∙HCl, R2 = H, R3 = 4-F (г); R1 = (CH2)2N(CH3)2∙HCl, R2 = H, R3 = 4-tC4H9 (д); R1 = (CH2)2N(CH3)2∙HCl, R2 = 4-NO2, R3 = H (е); R1 = (CH2)2N(C4H9)2, R2 = 4-OCH3, R3 = 2-Cl (ж).

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