Abstract
In Lipetsk region during 9 years a monitoring was implemented concerning immune status of children of preschool age residing in conditions of multi-factorial impact of environment. The sampling included 8,640 children. The examination implemented non-invasive screening techniques analyzing bactericidal activity of skin and composition of skin microflora. The children were allocated in three groups according their health: group I - healthy children; group II - children with functional and certain morphologic divergences and also decreased resistance to acute and chronic diseases; group III - children with chronic diseases at the stage of compensation with preserved functional possibilities of organism. The results of study demonstrated that bactericidal activity of skin within the limits of standard was established in 68% of children from group I, 65% of children from group II and 58% of children from group III. In the rest of children alterations were established related to composition of viable resident microflora being accompanied by increasing of index of bactericidal activity of skin or its drastic decreasing up to 37-58% that testifies disorder of adaptation compensation reactions of organisms of children to conditions of impact of unfavorable environment factors. In 10.4% of children from group III study established significant damage of structure of microbiocenosis of skin and Schneiderian membrane in direction of increasing of number of microorganisms with signs of pathogenicity occurring more often in boys than in girls that substantiates disorder of cellular immunity of organism in the given group of children. These children are included into the risk group for in-depth dispensary observation.
