Matrix Metalloproteinases in Oral Cancer Pathogenesis and their Use in Therapy
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Matrix Metalloproteinases in Oral Cancer Pathogenesis and their Use in Therapy |
| 2. | Creator | Author's name, affiliation, country | Stuti Maurya; Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus |
| 2. | Creator | Author's name, affiliation, country | Divya Prasad; Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus |
| 2. | Creator | Author's name, affiliation, country | Sayali Mukherjee; Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | Matrix metalloproteinases; oral cancer; SNP; microRNA; therapy; proteolytic enzymes; genetic polymorphism. |
| 4. | Description | Abstract | Matrix metalloproteinases (MMPs) are proteolytic enzymes that aid in extracellular matrix (ECM) remodeling. MMPs destroy the extracellular matrix, causing tumor growth and metastasis. MMPs are involved in the spread and metastasis of oral cancer. High levels of MMPs and oral squamous cell carcinoma have been linked to cancer prognosis. Modern medicine aims to prevent the illness from spreading through early intervention and examining changes in MMP genes. MMP gene polymorphism has recently been identified as one of the factors predicting susceptibility or risk in the development of oral carcinoma. This review aims to provide insight into the function of MMP subtypes involved in cancer. The genetic polymorphism in MMP genes and its predictive value in risk evaluation have been elaborated. Novel personalized therapeutic approaches for oral cancer, like the use of MMP inhibitors, nanoparticle-mediated targeting of MMP, or gene silencing by microRNA, can be designed. |
| 5. | Publisher | Organizing agency, location | Bentham Science |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 01.01.2024 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Research Article |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://vietnamjournal.ru/1871-5206/article/view/643671 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.2174/0118715206270002231108071917 |
| 11. | Source | Title; vol., no. (year) | Anti-Cancer Agents in Medicinal Chemistry; Vol 24, No 1 (2024) |
| 12. | Language | English=en | |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
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