Exploring the Theranostic Applications and Prospects of Nanobubbles


Дәйексөз келтіру

Толық мәтін

Аннотация

Anticancer medications as well as additional therapeutic compounds, have poor clinical effectiveness due to their diverse distribution, non-selectivity for malignant cells, and undesirable off-target side effects. As a result, ultrasound-based targeted delivery of therapeutic compounds carried in sophisticated nanocarriers has grown in favor of cancer therapy and control. Nanobubbles are nanoscale bubbles that exhibit unique physiochemical properties in both their inner core and outer shell. Manufacturing nanobubbles primarily aims to enhance therapeutic agents' bioavailability, stability, and targeted delivery. The small size of nanobubbles allows for their extravasation from blood vessels into surrounding tissues and site-specific release through ultrasound targeting. Ultrasound technology is widely utilized for therapy due to its speed, safety, and cost-effectiveness, and micro/nanobubbles, as ultrasound contrast agents, have numerous potential applications in disease treatment. Thus, combining ultrasound applications with NBs has recently demonstrated increased localization of anticancer molecules in tumor tissues with triggered release behavior. Consequently, an effective therapeutic concentration of drugs/genes is achieved in target tumor tissues with ultimately increased therapeutic efficacy and minimal side effects on other non-cancerous tissues. This paper provides a brief overview of the production processes for nanobubbles, along with their key characteristics and potential therapeutic uses.

Авторлар туралы

Rahul Shah

Department of Pharmaceutics, School of Pharmacy & Technology Management,, SVKM'S NMIMS Deemed-to-be University

Email: info@benthamscience.net

Niraj Phatak

Department of Pharmaceutics, School of Pharmacy & Technology Management,, SVKM'S NMIMS Deemed-to-be University

Email: info@benthamscience.net

Ashok Choudhary

Department of Quality Assurance, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University,

Email: info@benthamscience.net

Sakshi Gadewar

Department of Pharmaceutics, School of Pharmacy & Technology Management,, SVKM'S NMIMS Deemed-to-be University

Email: info@benthamscience.net

Ajazuddin

Department of Pharmaceutics, Rungta College of Pharmaceutical Sciences & Research

Email: info@benthamscience.net

Sankha Bhattacharya

Department of Pharmaceutics, School of Pharmacy & Technology Management,, SVKM'S NMIMS Deemed-to-be University

Хат алмасуға жауапты Автор.
Email: info@benthamscience.net

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