Acute toxicity of nanoscale form of 20-hydroxyecdysone in intragastric administration

封面

如何引用文章

全文:

详细

The nanoscale 20-hydroxyecdysone was first proposed and obtained in the form of a clathrate complex with arabinogalactan with an average particle size of 35,3 nm. The study of its acute toxicity has revealed that the product belongs to class VI of relatively harmless drugs according to Hodge and to class 5th in accordance with GOST 32644-2014.

作者简介

K. Erimbetov

All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition - a branch of the Federal Science Center of Animal Husbandry named after Academy Member L.K. Ernst; Research Center “Park of Active Molecules”

编辑信件的主要联系方式.
Email: erimbetovkt@mail.ru

Erimbetov Kenes Tagaevich

249013, Kaluga Region
249030, Obninsk, Kaluga Region

俄罗斯联邦

A. Fedorova

All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition - a branch of the Federal Science Center of Animal Husbandry named after Academy Member L.K. Ernst

Email: ledifav@yandex.ru

Fedorova Alena Vladimirovna

249013, Kaluga Region

俄罗斯联邦

A. Goncharova

Research Center “Park of Active Molecules”

Email: goncharova@pam-alliance.ru

Goncharova Anna Yakovlevna

249030, Obninsk, Kaluga Region

俄罗斯联邦

O. Obvintseva

All-Russian Research Institute of Physiology, Biochemistry and Animal Nutrition - a branch of the Federal Science Center of Animal Husbandry named after Academy Member L.K. Ernst

Email: obvintseva.olga@yandex.ru

Obvintseva Olga Vital′evna

249013, Kaluga Region

俄罗斯联邦

参考

  1. Volodin V.A., Sidorova Yu.S., Maso V.K. 20-hydroxyecdysone -a plant adaptogen: anabolic effect, possible use in sports nutrition // Nutrition Issues. 2013; 82 (6): 24-30. (In Russian)
  2. Anthony T.G., Mirek E.T., Bargoud A.R., Phillipson-Weiner L, DeOliveira C.M., Wetstein B., Graf B.L., Kuhn P.E., Raskin I. Evaluating the effect of 20-hydroxyecdysone (20HE) on mechanistic target of rapamycin complex 1 (mTORC1) signaling in the skeletal muscle and liver of rats // Appl. Physiol. Nutr. Metabol. 2015; 40:1324-1328.
  3. Erimbetov K.T., Obvintseva O.V., Fedorova A.V., Zemlyanoy R.A., Solovieva A.G. Phenotypic regulation of animal skeletal muscle protein metabolism // Ukrainian Journal of Ecology. 2019; 9 (4):651-656.
  4. Kumar R.N., Sundaram R., Shanthi P. Protective role of 20-OH ecdysone on lipid profile and tissue fatty acid changes in streptozotocin induced diabetic rats // European Journal of Pharmacology. 2013; 698 (1–3):489– 498.
  5. Roziev R.A. et al. Clathrate complex of arabinogalactan or gum arabic with 20-hydroxyecdysone, method for its preparation (options), pharmaceutical composition and drug // Patent RF, N 2572334; 2016. (In Russian)
  6. Fedorova A.V., Erimbetov K.T., Bondarenko E.V., Goncharova A.Ya., Frog E.S. Development of a nanoscale form of 20-hydroxyecdysone // Russian Journal of Experimental and Clinical Pharmacology. 2018; 81: 254. (In Russian)
  7. Guidelines for preclinical studies of drugs. Part one. Edited by A. Mironov - M.: Grif and K, 2012-944 p. (In Russian)
  8. Drug safety: from preclinic to clinic: monograph. Edited by A.L. Khokhlova. Moscow-Yaroslavl: LLC Photolife, 2018, -275 p. (In Russian)
  9. GOST-32644-2014 Test methods for the effects of chemical products on the human body. Acute oral toxicity is a method for determining the class of acute toxicity. 2015. (In Russian)
  10. Hodge H.C., Gosselin R.E., Smith R.P., Gleason M.N. Clinical Toxicology of Commercial Products // Acute Poisoning. 4th ed., Williams & Wilkins, Baltimore. 1975; 427.
  11. Zhavoronkov L.P. Fundamentals of applied biomedical statistics. Toolkit. Obninsk: Federal State Budgetary Institution MRRC of the Ministry of Health and Social Development of Russia. 2012. - 60 p. (In Russian)
  12. Ogawa S., Nishimoto N., Matsuda H. Pharmacology of ecdysones in vertebrates // Invertebrate endocrinology and hormonal heterophylly / Ed. W.J. Burdette. Berlin: Springler, 1974. P. 341-344.
  13. Prozorovsky V.B. Statistical processing of pharmacological research results. Psychopharmacology and biological narcology. 2007; 7 (3): 2090-2120. (In Russian)

补充文件

附件文件
动作
1. JATS XML
下载

版权所有 © Erimbetov K.T., Fedorova A.V., Goncharova A.Y., Obvintseva O.V., 2021


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 81728 от 11 декабря 2013.