BLOOD ESTRERASE PROFILE IN MICE AT ACUTE INTOXICATION BY 2-(О-CRESYL)-4Н-1,3,2- BENZODIOXAPHOSPHORIN-2-OXIDE

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Resumo

The influence of 2-(o-cresyl)-4H-1,3,2-benzodioxaphosphorin-2-oxide (CBDP) on the blood esterase profile in mice was studied at different doses an hour and 24 h after its subcutaneous administration to animals. It is established that CBDP is not a specific carboxyl esterase inhibitor in mice blood serum as it equally inhibits blood butyrylcholinesterase as well. CBDP is a low effective acetylcholinesterase inhibitor in mice blood serum and does not pose an expressed effect in respect to acetylcholinesterase in erythrocytes membranes, however in high doses it is able to lower their amount.

Sobre autores

D. Prokofieva

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Autor responsável pela correspondência
Email: noemail@neicon.ru
Rússia

V. Shmurak

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Rússia

A. Krivoshein

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Rússia

E. Bodryakova

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Rússia

N. Voitenko

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru
Rússia

Bibliografia

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Declaração de direitos autorais © Prokofieva D.S., Shmurak V.I., Krivoshein A.E., Bodryakova E.A., Voitenko N.G., 2016


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