Three-component heterocyclization of 5-(arylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-triones with isoquinoline and dimethyl but-2-ynedioate

The reaction of 5-(arylmethylidene)-2,4,6-pyrimidine-2,4,6(1Н,3Н,5Н)-triones with isoquinoline and dimethylbut-2-indioate ends with the formation of cycloaddition products – substituted dimethyl- 2-aryl –1,1b-dihydro-2H-spiro[pyrimidine-5,1′-pyrido[2,1-a]isoquinoline-2,4,6(1H,3H,5H)-trione]-3,4-dicarboxylates. The latter react with an excess of KOH in ethanol to form dipotassium salts 2-aryl –1,1b-dihydro-2H-spiro[pyrimidine-5,1′-pyrido[2,1-a]isoquinoline-2,4,6(1H,3H,5H)-trione]-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculous and fungicidal activity.