Neonatal Hypoxia Induces Behavioral Deficit Associated with Impairment in the Glucocorticoid and Serotonergic Systems in Adult Rats
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Neonatal Hypoxia Induces Behavioral Deficit Associated with Impairment in the Glucocorticoid and Serotonergic Systems in Adult Rats |
| 2. | Creator | Author's name, affiliation, country | E. I. Tyulkova; Pavlov Institute of Physiology of the Russian Academy of Sciences; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | V. A. Stratilov; Pavlov Institute of Physiology of the Russian Academy of Sciences; Russian Federation |
| 2. | Creator | Author's name, affiliation, country | O. V. Vetrovoy; Pavlov Institute of Physiology of the Russian Academy of Sciences; Russian Federation |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | rats; neonatal hypoxia; glucocorticoid system; serotonin system; behavior |
| 4. | Description | Abstract | We investigated the behavioral responses, raphe serotonin levels, and serum concentrations of adrenocorticotropic hormone (ACTH), corticosterone, and serotonin in adult rats subjected to three sessions of hypobaric hypoxia (360 mmHg, 2 hours each) within 8-10 days post-partum. This non-invasive rat model of neonatal hypoxia (NH) simulates mild perinatal hypoxic trauma in fetuses and premature infants. At 3 months of age, NH-exposed rats exhibited reduced exploratory behavior and increased anxiety in both the open field and plus maze tests. These behavioral changes were accompanied by decreased serotonin levels in the raphe nuclei. In the blood serum of adult NH-exposed rats, corticosterone and serotonin levels remained unaltered, while ACTH levels showed a significant decrease. Our findings suggest that early postnatal hypoxic stress disrupts the serotonin system and alters HPA axis function, leading to long-lasting behavioral changes. |
| 5. | Publisher | Organizing agency, location | The Russian Academy of Sciences |
| 6. | Contributor | Sponsor(s) |
Government of the Russian Federation (1023032400236-8-3.1.4) |
| 7. | Date | (DD-MM-YYYY) | 13.12.2024 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Research Article |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://vietnamjournal.ru/0044-4529/article/view/648114 |
| 10. | Identifier | Digital Object Identifier (DOI) | 10.31857/S0044452924050079 |
| 10. | Identifier | eLIBRARY Document Number (EDN) | XPCSUR |
| 11. | Source | Title; vol., no. (year) | Žurnal èvolûcionnoj biohimii i fiziologii; Vol 60, No 5 (2024) |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files |
Fig. 1. Study design. NH, neonatal hypoxia; p0, day of birth; p8, p9, p10, p90, postnatal days; d1, d4, d10, days of experiment; OFT, open-field test, EPM, elevated cruciform maze test (23KB) Fig. 2. Effect of neonatal hypoxia (NH) on ACTH (ACTH) (a, d), corticosterone (CS) (b, e) and serotonin (5HT) (c, f) concentrations in serum of 2-week-old (a-c) and 3-month-old (d-f) rats (41KB) Fig. 3. Effect of neonatal hypoxia (NH) on serotonin (5HT) concentration in the Schwa Nuclei (RN) of 3-month-old rats (7KB) Fig. 4. Effect of neonatal hypoxia (NH) on the number of cross sections in the peripheral zone (peripheral activity) (a), central zone (central activity) (b), number of uprights (upright activity) (c), number of acts of hole exploration (burrowing) (d) and grooming time (e) in adult rats in the open-field test (37KB) Fig. 5. Effect of neonatal hypoxia (NH) on time spent in and open arms (a), closed arms (b), centre platform (c), number of transitions between closed arms (d), hovering from open arms (e) and grooming time (f) of adult rats in the elevated cruciform maze test (40KB) |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
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