Cell and Tissue BiologyCell and Tissue BiologyЦитология0041-37713034-6061The Russian Academy of Sciences66956510.31857/S0041377123020062LWRDIVArticlesСтатьиActivation of Endogenous Mesenchymal Stromal Cells as an Approach to Tissue RegenerationАктивация эндогенных мезенхимных стромальных клеток как подход к регенерации тканейPayushinaO. V.ПаюшинаО. В.payushina@mail.ruTsomartovaD. A.ЦомартоваД. А.payushina@mail.ruChereshnevaYe. V.ЧерешневаЕ. В.payushina@mail.ruIvanovaM. Yu.ИвановаМ. Ю.payushina@mail.ruLomanovskayaT. A.ЛомановскаяТ. А.payushina@mail.ruPavlovaM. S.ПавловаМ. С.payushina@mail.ruKuznetsovS. L.КузнецовС. Л.payushina@mail.ruSechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России0103202365211913027022025Copyright ©; 2023, О.В. Паюшина, Д.А. Цомартова, Е.В. Черешнева, М.Ю. Иванова, Т.А. Ломановская, М.С. Павлова, С.Л. КузнецовCopyright ©; 2023, О.В. Паюшина, Д.А. Цомартова, Е.В. Черешнева, М.Ю. Иванова, Т.А. Ломановская, М.С. Павлова, С.Л. Кузнецов2023О.В. Паюшина, Д.А. Цомартова, Е.В. Черешнева, М.Ю. Иванова, Т.А. Ломановская, М.С. Павлова, С.Л. КузнецовО.В. Паюшина, Д.А. Цомартова, Е.В. Черешнева, М.Ю. Иванова, Т.А. Ломановская, М.С. Павлова, С.Л. Кузнецовhttps://vietnamjournal.ru/0041-3771/article/view/669565

Mesenchymal stromal cells (MSCs) which have a complex pro-regenerative effect on damaged tissues represent a promising resource for cell therapy for a wide range of diseases. However, transplantation of autologous or donor MSCs to a patient is associated with a number of problems, such as variability of cell properties depending on their source and cultivation conditions, a decrease in their therapeutic potential and the possibility of acquiring immunogenicity or tumorigenicity during in vitro expansion, and the invasiveness of the isolation procedure. One of the ways to avoid these problems can be the impact on endogenous MSCs by stimulating their directed migration into tissue defects, without the need for extraction from the body, in vitro cultivation and reintroduction to the patient. This review discusses approaches to activating the mobilization of MSCs from tissue niches and/or stimulating their migration to the target area, which can be considered as a safer, and possibly more effective alternative to MSC transplantation.

Мезенхимные стромальные клетки (МСК), оказывающие комплексное прорегенеративное влияние на поврежденные ткани, представляют собой перспективный ресурс для клеточной терапии широкого спектра заболеваний. Однако трансплантация пациенту аутологичных или донорских МСК сопряжена с рядом проблем, таких как вариабельность свойств клеток в зависимости от источника и условий культивирования, снижение их терапевтического потенциала и вероятность приобретения иммуногенности либо туморогенности в ходе экспансии in vitro, инвазивность процедуры выделения. Одним из способов избежать этих проблем может служить воздействие на эндогенные МСК путем стимуляции их направленной миграции в тканевые дефекты без необходимости извлечения из организма, размножения in vitro и обратного введения пациенту. В настоящем обзоре рассмотрены подходы к активации мобилизации МСК из тканевых ниш и (или) стимуляции их миграции в целевую область, которые могут рассматриваться в качестве более безопасной, а возможно, и более эффективной альтернативы трансплантации МСК.

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