Cell and Tissue BiologyCell and Tissue BiologyЦитология0041-37713034-6061The Russian Academy of Sciences66953110.31857/S004137712306007XORQQEYArticlesСтатьиStructural and Functional Features of Bacterial SMC ComplexesОсобенности структуры и функций бактериальных комплексов SMCMorozovaN. E.МорозоваН. Е.misterkotlin@gmail.comPotysyevaA. S.ПотысьеваА. С.misterkotlin@gmail.comVedyaykinA. D.ВедяйкинА. Д.misterkotlin@gmail.comPeter the Great St. Petersburg Polytechnic University, NIK “Nanobiotechnologies”,Научно-исследовательский комплекс “Нанобиотехнологии” Санкт-Петербургского политехнического университета Петра Великого0111202365652253427022025Copyright ©; 2023, Н.Е. Морозова, А.С. Потысьева, А.Д. ВедяйкинCopyright ©; 2023, Н.Е. Морозова, А.С. Потысьева, А.Д. Ведяйкин2023Н.Е. Морозова, А.С. Потысьева, А.Д. ВедяйкинН.Е. Морозова, А.С. Потысьева, А.Д. Ведяйкинhttps://vietnamjournal.ru/0041-3771/article/view/669531

SMC complexes (Structural maintenance of chromosomes) are key participants in the spatial organization of DNA in all living organisms – in bacteria, archaea and eukaryotes. In bacteria, there are several homologues of SMC complexes that perform seemingly unrelated functions, but function through very similar, highly conserved mechanisms. In recent years, it has been established that SMC complexes are capable of forming loops from DNA (through the so-called loop extrusion), which allows them to be considered as a separate class of DNA translocases. This paper discusses bacterial SMC complexes in comparison with their homologues such as MukBEF, MksBEF, RecN, and Wadjet, as well as with eukaryotic SMC complexes. Their properties, role and functions in the key processes of the bacterial cell are discussed.

Белковые комплексы SMC (от англ. Structural maintenance of chromosomes, далее в тексте – комплексы SMC) являются ключевыми участниками пространственной организации ДНК во всех живых организмах – в бактериях, археях и эукариотах. У бактерий имеется несколько гомологов комплексов SMC, которые выполняют, на первый взгляд, несвязанные друг с другом функции, однако действуют посредством очень похожих между собой, высококонсервативных механизмов. За последние годы установлено, что комплексы SMC способны осуществлять формирование петель ДНК (посредством так называемой экструзии петель), что позволяет рассматривать их как отдельный класс ДНК-транслоказ. В данной работе обсуждаются бактериальные комплексы SMC в сравнении с их гомологами, такими как MukBEF, MksBEF, RecN и Wadjet, а также с комплексами SMC эукариот. Обсуждаются их свойства, роль и функции в ключевых процессах бактериальной клетки.

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