Cell and Tissue BiologyCell and Tissue BiologyЦитология0041-37713034-6061The Russian Academy of Sciences66950110.31857/S0041377124040053QCQFVMArticlesСтатьиResearch ArticleEffect of nanocluster polyoxometalate {mo72fe30} on morphofunctional state of macrophages in culturesВлияние нанокластерного полиоксометаллата {мo72fe30} на морфофункциональное состояние макрофагов в культуреTitovaS. A.ТитоваС. А.
Russian Federation
svetattitova12021998@gmail.comTonkushinaM. O.ТонкушинаМ. О.
Russian Federation
svetattitova12021998@gmail.comGrzhegorzhevskiiK. V.ГржегоржевскийК. В.
Russian Federation
svetattitova12021998@gmail.comDanilovaI. G.ДаниловаИ. Г.
Russian Federation
svetattitova12021998@gmail.comPozdinaV. A.ПоздинаВ. А.
Russian Federation
svetattitova12021998@gmail.comUlitkoM. V.УлиткоМ. В.
Russian Federation
svetattitova12021998@gmail.comOstroushkoA. A.ОстроушкоА. А.
Russian Federation
svetattitova12021998@gmail.comUral Federal University named after the First President of Russia B. N. YeltsinУральский федеральный университет им. Первого Президента России Б.Н. ЕльцинаInstitute of Immunology and Physiology, Urals Branch, Russian Academy of SciencesИнститут иммунологии и физиологии Уральского отделения РАН1507202466436737927022025Copyright ©; 2024, Russian Academy of SciencesCopyright ©; 2024, Российская академия наук2024Russian Academy of SciencesРоссийская академия наукhttps://vietnamjournal.ru/0041-3771/article/view/669501

The aim of this work was to study the effect of nanocluster polyoxometalate {Mo72Fe30} on the macrophage link of the immune system. In vitro studies of polyoxometalate on macrophage cultures allowed us to evaluate the reaction of immune system cells (in particular, peritonial and alveolar macrophages) to nanoparticles. The analysis of the obtained data allowed to establish that {Mo72Fe30} is not toxic for peritonial and alveolar macrophages, has no significant effect on the morphology of cells, as well as on the activity of α-naphthylacetate esterase. However, it significantly reduces phagocytic activity when cells are cultured with POM, which may indicate possible polarisation of macrophages. The obtained results confirm the possibility of using {Mo72Fe30} in the field of biomedicine.

Цель данной работы – оценка влияния нанокластерного полиоксометаллата {Мо72Fe30}, перспективного в качестве основы для средств адресной доставки лекарств в организме, на морфологию, фенотип, функциональную активность перитонеальных и альвеолярных макрофагов. Показано, что {Мо72Fe30} не токсичен для перитонеальных и альвеолярных макрофагов, не оказывает значимого влияния на морфологию клеток и на активность α-нафтилацетатэстеразы. Введение {Мо72Fe30} способствует снижению фагоцитарной активности и числа СD163+-макрофагов в культуре, стимулирует поляризацию макрофагов в направлении фенотипа М1.

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