Genome-Wide Analysis of the Risk Association for the Development of Paranoid Schizophrenia in Russians: Search for Genetic Markers in the 1q43 Chromosomal Region

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Abstract

Schizophrenia is a highly hereditary disorder. Genetic risk is associated with a large number of alleles, including common alleles with little effect that can be found in genome-wide association studies. The aim of this study was to study genetic risk factors for the development of schizophrenia in a genome-wide association analysis (GWAS) in Russians from the Republic of Bashkortostan. The studied sample consisted of 320 patients with paranoid schizophrenia and 402 healthy individuals. GWAS genotyping of DNA samples was carried out on the PsychChip biochip, which included 610,000 single nucleotide polymorphic variants (SNPs).

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A. E. Gareeva

Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences; Kemerovo State University of the Ministry of Science and Higher Education of the Russian Federation; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: annagareeva@yandex.ru
Russian Federation, Ufa; Kemerovo; Moscow

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2. Fig. 1. Graphic representation of the results of a genome-wide analysis of the association of 395832 SNPs with paranoid schizophrenia in Russians (Manhattan plot). The X axis shows the chromosomal localization of SNPs, and the Y axis shows the values ​​of the negative decimal logarithm of the p-value significance level.

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